HitPredict

Interactor 1: GBRAP (O95166)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gene: GABARAP

Interactor 2: KBTB7 (Q8WVZ9)
Kelch repeat and BTB domain-containing protein 7
Gene: KBTBD7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.852

Property	Details
Experiments	25684205, 20562859
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, peptide array, isothermal titration calorimetry
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	ATG8~KBTB_W-LIR
Common GO terms	GO:0005829 - cytosol GO:0035020 - regulation of Rac protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 117 Hs			1 684
+	Hs
		952265 GBRL2_HUMAN (1-117): 2.76e-58: 176: 57.27		KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00
+	Hs
		1358852 GBRL1_HUMAN (1-116): 8.18e-56: 170: 87.07		KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00
+	Hs
		952228 GBRL2_HUMAN (1-117): 2.76e-58: 176: 57.27		KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76
+	Hs
		328058 GBRAP_HUMAN (1-117): 8.09e-57: 173: 100.00		KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76
+	Hs
		1358856 MLP3A_HUMAN (5-117): 2.3e-45: 144: 30.44		KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00
+	Hs
		1358844 MLP3C_HUMAN (5-116): 1.16e-44: 143: 38.60		KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00
+	Hs
		1290299 GBRL1_HUMAN (1-116): 8.18e-56: 170: 87.07		KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76
+	Hs
		1358849 MLP3B_HUMAN (2-117): 3.56e-44: 141: 30.51		KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00
+	Hs
		1290302 MLP3A_HUMAN (5-117): 2.3e-45: 144: 30.44		KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76
+	Hs
		1290293 MLP3C_HUMAN (5-116): 1.16e-44: 143: 38.60		KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76
+	Hs
		1290297 MLP3B_HUMAN (2-117): 3.56e-44: 141: 30.51		KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76
+	Hs
		952160 GBRL2_HUMAN (1-117): 2.76e-58: 176: 57.27		KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42
+	Hs
		328002 GBRAP_HUMAN (1-117): 8.09e-57: 173: 100.00		KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42
+	Hs
		1121523 GBRL1_HUMAN (1-116): 8.18e-56: 170: 87.07		KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42
+	Hs
		1121526 MLP3A_HUMAN (5-117): 2.3e-45: 144: 30.44		KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42
+	Hs
		1121519 MLP3B_HUMAN (2-117): 3.56e-44: 141: 30.51		KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42
+	Hs
		952295 GBRL2_HUMAN (1-117): 2.76e-58: 176: 57.27		KLHL5_HUMAN (276-483): 1.18e-25: 114: 16.06
+	Dm
		1269043 Q9W2S2_DROME (1-117): 5.31e-58: 176: 91.45		Q7KSF5_DROME (355-482): 1.3e-23: 108: 16.28
+	Hs
		1199037 MLP3A_HUMAN (5-117): 2.3e-45: 144: 30.44		KLH12_HUMAN (510-684): 1.5e-18: 91.9: 12.43
+	Hs
		1199032 MLP3B_HUMAN (2-117): 3.56e-44: 141: 30.51		KLH12_HUMAN (510-684): 1.5e-18: 91.9: 12.43