HitPredict

Interactor 1: KBTB7 (Q8WVZ9)
Kelch repeat and BTB domain-containing protein 7
Gene: KBTBD7

Interactor 2: GBRL1 (Q9H0R8)
Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Gene: GABARAPL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	25684205, 25416956, 20562859
Identification Methods	affinity chromatography technology, two hybrid, pull down, unspecified method, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid, isothermal titration calorimetry
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	ATG8~KBTB_W-LIR
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 684 Hs			1 117
+	Hs
		952265 KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		328087 KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00		GBRAP_HUMAN (1-116): 2.97e-56: 171: 87.07
+	Hs
		952228 KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1290299 KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76		GBRL1_HUMAN (1-117): 4.56e-56: 171: 100.00
+	Hs
		1358844 KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00		MLP3C_HUMAN (5-116): 1.62e-44: 143: 39.47
+	Hs
		328058 KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76		GBRAP_HUMAN (1-116): 2.97e-56: 171: 87.07
+	Hs
		1358856 KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00		MLP3A_HUMAN (5-116): 1.1e-44: 142: 34.21
+	Hs
		1358849 KBTB7_HUMAN (1-684): 1.24e-171: 508: 100.00		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		1290293 KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76		MLP3C_HUMAN (5-116): 1.62e-44: 143: 39.47
+	Hs
		1290302 KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76		MLP3A_HUMAN (5-116): 1.1e-44: 142: 34.21
+	Hs
		1290297 KBTB6_HUMAN (1-674): 7.4e-161: 480: 89.76		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		952160 KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1121523 KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42		GBRL1_HUMAN (1-117): 4.56e-56: 171: 100.00
+	Hs
		328002 KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42		GBRAP_HUMAN (1-116): 2.97e-56: 171: 87.07
+	Hs
		1121526 KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42		MLP3A_HUMAN (5-116): 1.1e-44: 142: 34.21
+	Hs
		1121519 KEAP1_HUMAN (470-682): 1.89e-37: 150: 15.42		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		952295 KLHL5_HUMAN (276-483): 1.18e-25: 114: 16.06		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Dm
		1269043 Q7KSF5_DROME (355-482): 1.3e-23: 108: 16.28		Q9W2S2_DROME (1-116): 1.57e-57: 175: 85.35
+	Hs
		1399935 KLHL5_HUMAN (276-483): 1.18e-25: 114: 16.06		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		1199032 KLH12_HUMAN (510-684): 1.5e-18: 91.9: 12.43		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62