HitPredict

Interactor 1: EGLN2 (Q96KS0)
Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)
Gene: EGLN2

Interactor 2: EGLN3 (Q9H6Z9)
Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)
Gene: EGLN3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

The method score is based on:

Property	Details
Experiments	16958618, 24145445
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	2OG-FeII_Oxy_3~2OG-FeII_Oxy_3
Common GO terms	GO:0001666 - response to hypoxia GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008198 - ferrous iron binding and 7 others more... GO:0016706 - 2-oxoglutarate-dependent dioxygenase activity GO:0018401 - peptidyl-proline hydroxylation to 4-hydroxy-L-proline GO:0031418 - L-ascorbic acid binding GO:0031545 - peptidyl-proline 4-dioxygenase activity GO:0043523 - regulation of neuron apoptotic process GO:0071456 - cellular response to hypoxia GO:0160082 - hypoxia-inducible factor-proline dioxygenase activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	407
Hs

1	239

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024