Protein: UBP1
Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]

Gene: UBP1, USP1
Organism: Homo sapiens
Interactions: 127
UniProt ID: O94782

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317197

WDR48
WD repeat-containing protein 48

25

15

Small-scale

0.992

High

317217

FACD2
Fanconi anemia group D2 protein

8

1

Small-scale

0.967

High

317127

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

20

Small-scale

0.888

High

247197

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

8

7

Small-scale

0.754

High

317130

PCNA
Proliferating cell nuclear antigen

8

1

Small-scale

0.751

High

317148

IMA5
Importin subunit alpha-5

6

7

Small-scale

0.739

High

317223

FANCI
Fanconi anemia group I protein

4

1

Small-scale

0.694

High

317205

R51A1
RAD51-associated protein 1

4

2

Small-scale

0.694

High

317144

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.691

High

317167

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

18

High-throughput

0.691

High

317190

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

17

High-throughput

0.691

High

317189

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

3

7

Small-scale

0.667

High

317126

PARP1
Poly [ADP-ribose] polymerase 1

2

4

Small-scale

0.634

High

317149

STAT2
Signal transducer and activator of transcription 2

2

4

High-throughput

0.628

High

317122

MYC
Myc proto-oncogene protein

2

10

Small-scale

0.624

High

317226

FZR1
Fizzy-related protein homolog

2

9

Small-scale

0.624

High

275862

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

15

High-throughput

0.618

High

317118

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

16

Small-scale

0.618

High

317158

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

15

High-throughput

0.618

High

317199

WDR20
WD repeat-containing protein 20

1

20

High-throughput

0.618

High

155986

SOCS6
Suppressor of cytokine signaling 6

2

4

High-throughput

0.611

High

317177

IMB1
Importin subunit beta-1

2

2

Small-scale

0.611

High

317227

KLDC2
Kelch domain-containing protein 2

2

4

Small-scale

0.608

High

317147

IMA1
Importin subunit alpha-1

2

7

High-throughput

0.601

High

317182

SGO1
Shugoshin 1

2

2

High-throughput

0.601

High

317222

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.586

High

317211

ATAD5
ATPase family AAA domain-containing protein 5

2

3

Small-scale

0.584

High

317202

LRC15
Leucine-rich repeat-containing protein 15

2

3

High-throughput

0.574

High

188560

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

1

1

Small-scale

0.561

High

317155

MAX
Protein max

1

10

Small-scale

0.561

High

317180

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

Small-scale

0.561

High

317221

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.561

High

317198

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.549

High

317210

OPALI
Opalin

2

2

High-throughput

0.549

High

317132

EZRI
Ezrin

1

1

High-throughput

0.541

High

250379

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.536

High

317125

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.536

High

317131

PLAK
Junction plakoglobin

1

13

High-throughput

0.536

High

317134

FILA
Filaggrin

1

7

High-throughput

0.536

High

317139

MYH9
Myosin-9

1

6

High-throughput

0.536

High

317141

TAGL2
Transgelin-2

1

5

High-throughput

0.536

High

317164

DSG1
Desmoglein-1

1

3

High-throughput

0.536

High

317165

K1C17
Keratin, type I cytoskeletal 17

1

4

High-throughput

0.536

High

317173

PKP1
Plakophilin-1

1

9

High-throughput

0.536

High

317181

TAZ
Tafazzin

2

1

Small-scale

0.533

High

317146

LEG7
Galectin-7

1

0

High-throughput

0.513

High

317183

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.513

High

317212

SORT
Sortilin

1

0

High-throughput

0.513

High

317215

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.513

High

317220

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

317162

TAGL
Transgelin

1

6

Small-scale

0.512

High

317154

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

1

Small-scale

0.501

High

282437

KTNA1
Katanin p60 ATPase-containing subunit A1

1

4

High-throughput

0.489

High

317135

CALL3
Calmodulin-like protein 3

1

2

High-throughput

0.489

High

317137

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

317157

LYSC
Lysozyme C

1

1

High-throughput

0.489

High

317166

DSC1
Desmocollin-1

1

1

High-throughput

0.489

High

317184

SPXN5
Sperm protein associated with the nucleus on the X chromosome N5

1

2

High-throughput

0.489

High

317186

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

2

High-throughput

0.489

High

317192

UBE3B
Ubiquitin-protein ligase E3B

1

4

High-throughput

0.489

High

317195

A16A1
Aldehyde dehydrogenase family 16 member A1

1

1

High-throughput

0.489

High

317207

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

5

High-throughput

0.489

High

317224

CALL5
Calmodulin-like protein 5

1

4

High-throughput

0.489

High

317196

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

1

High-throughput

0.481

High

317216

PHF7
E3 ubiquitin-protein ligase PHF7

1

2

High-throughput

0.481

High

317228

TRAF6
TNF receptor-associated factor 6

1

11

High-throughput

0.481

High

317119

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.480

High

72363

IMA8
Importin subunit alpha-8

1

7

Small-scale

0.479

High

138605

IMA4
Importin subunit alpha-4

1

7

Small-scale

0.479

High

163026

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

179014

IMA6
Importin subunit alpha-6

1

7

Small-scale

0.479

High

188631

BIRC5
Baculoviral IAP repeat-containing protein 5

1

1

Small-scale

0.479

High

279084

ULK1
Serine/threonine-protein kinase ULK1

1

5

Small-scale

0.479

High

317120

NFAT5
Nuclear factor of activated T-cells 5

1

5

Small-scale

0.479

High

317121

SNAI1
Zinc finger protein SNAI1

1

7

Small-scale

0.479

High

317123

ESR1
Estrogen receptor

1

8

Small-scale

0.479

High

317124

CPNS1
Calpain small subunit 1

1

1

Small-scale

0.479

High

317129

BCR
Breakpoint cluster region protein

1

2

Small-scale

0.479

High

317136

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

Small-scale

0.479

High

317138

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

6

Small-scale

0.479

High

317140

ZEB1
Zinc finger E-box-binding homeobox 1

1

5

Small-scale

0.479

High

317143

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

317145

NOTC1
Neurogenic locus notch homolog protein 1

1

8

Small-scale

0.479

High

317150

PLK1
Serine/threonine-protein kinase PLK1

1

9

Small-scale

0.479

High

317152

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.479

High

317153

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

4

High-throughput

0.479

High

317156

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

317159

RS16
Small ribosomal subunit protein uS9

1

4

Small-scale

0.479

High

317160

RS18
Small ribosomal subunit protein uS13

1

3

Small-scale

0.479

High

317161

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

Small-scale

0.479

High

317163

ID2
DNA-binding protein inhibitor ID-2

1

1

Small-scale

0.479

High

317168

TRAF3
TNF receptor-associated factor 3

1

11

Small-scale

0.479

High

317170

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

3

Small-scale

0.479

High

317171

CUL1
Cullin-1

1

4

Small-scale

0.479

High

317172

CUL4A
Cullin-4A

1

4

High-throughput

0.479

High

317174

CIRBP
Cold-inducible RNA-binding protein

1

4

High-throughput

0.479

High

317175

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

4

Small-scale

0.479

High

317176

GOGB1
Golgin subfamily B member 1

1

11

High-throughput

0.479

High

317178

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

10

Small-scale

0.479

High

317179

SIX1
Homeobox protein SIX1

1

1

Small-scale

0.479

High

317191

SPT6H
Transcription elongation factor SPT6

1

1

Small-scale

0.479

High

317203

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

2

Small-scale

0.479

High

317204

KAT2A
Histone acetyltransferase KAT2A

1

12

Small-scale

0.479

High

317213

VRK1
Serine/threonine-protein kinase VRK1

1

2

Small-scale

0.479

High

317214

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

2

Small-scale

0.479

High

317218

WWTR1
WW domain-containing transcription regulator protein 1

1

5

Small-scale

0.479

High

317225

TBK1
Serine/threonine-protein kinase TBK1

1

5

Small-scale

0.479

High

130335

SPT5H
Transcription elongation factor SPT5

1

0

Small-scale

0.458

High

317128

KIT
Mast/stem cell growth factor receptor Kit

1

0

Small-scale

0.458

High

317194

TM192
Transmembrane protein 192

1

0

Small-scale

0.458

High

317209

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

317219

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.458

High

317133

K2C4
Keratin, type II cytoskeletal 4

1

2

High-throughput

0.445

High

317193

TRI46
Tripartite motif-containing protein 46

1

6

High-throughput

0.439

High

158742

AP3D1
AP-3 complex subunit delta-1

1

2

Small-scale

0.437

High

317142

HSPA9
Stress-70 protein, mitochondrial

1

10

Small-scale

0.437

High

317169

OS9
Protein OS-9

1

1

Small-scale

0.437

High

66986

AXA2L
Putative annexin A2-like protein

1

0

High-throughput

0.426

High

317208

EAF1
ELL-associated factor 1

1

0

High-throughput

0.426

High

317151

VMAT1
Chromaffin granule amine transporter

1

1

High-throughput

0.407

High

317185

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

2

High-throughput

0.407

High

317201

HUMMR
Protein MGARP

2

0

High-throughput

0.313

High

317187

CHIC1
Cysteine-rich hydrophobic domain-containing protein 1

1

0

High-throughput

0.279

Low

317200

CERK1
Ceramide kinase

1

0

High-throughput

0.279

Low

317188

GOLM2
Protein GOLM2

1

0

Small-scale

0.249

Low

317206

ZN428
Zinc finger protein 428

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025