HitPredict

Interactor 1: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071664
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~BTB
Common GO terms	GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0008270 - zinc ion binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1834 Hs			1 777
+	Hs
		1311333 SLX4_HUMAN (1-1834): 0: 1473: 100.00		ANKH1_HUMAN (101-651): 2.72e-65: 239: 14.18
+	Hs
		1250616 SLX4_HUMAN (1-1834): 0: 1473: 100.00		BCOR_HUMAN (152-543): 7.62e-45: 176: 23.93
+	Hs
		274190 SLX4_HUMAN (1-1834): 0: 1473: 100.00		ANR17_HUMAN (165-431): 1.06e-19: 96.9: 10.66
+	Hs
		854254 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		BARD1_HUMAN (1-777): 0: 649: 100.00
+	Hs
		1129715 MDC1_HUMAN (757-1462): 4.4e-17: 90.6: 10.56		BARD1_HUMAN (1-777): 0: 649: 100.00
+	Hs
		1273861 MICA3_HUMAN (1139-1747): 8.47e-13: 76.3: 10.24		BARD1_HUMAN (1-777): 0: 649: 100.00
+	Mm
		109271 ANK2_MOUSE (800-1719): 3.46e-49: 196: 12.66		ANK3_MOUSE (130-480): 1.78e-43: 172: 14.37
+	Hs
		1129742 MDC1_HUMAN (757-1462): 4.4e-17: 90.6: 10.56		TNKS2_HUMAN (266-729): 8.95e-68: 245: 15.75
+	Hs
		1439088 MAGE1_HUMAN (868-1286): 2.87e-11: 70.8: 9.26		KDIS_HUMAN (195-609): 3.69e-63: 232: 15.40
+	Hs
		332404 MDC1_HUMAN (757-1462): 4.4e-17: 90.6: 10.56		TNKS1_HUMAN (291-563): 3.31e-46: 180: 18.04
+	Hs
		1091420 MICA3_HUMAN (1139-1747): 8.47e-13: 76.3: 10.24		ANK3_HUMAN (130-480): 1.69e-43: 173: 14.09
+	Hs
		861124 MAP1B_HUMAN (819-1706): 3.35e-10: 67.8: 10.90		ANK2_HUMAN (135-447): 8.22e-34: 142: 8.92
+	Hs
		1253891 SRCAP_HUMAN (982-1802): 3.8e-21: 104: 10.50		X5D778_HUMAN (410-509): 9.5e-22: 100: 51.00
+	Hs
		1030692 ANK2_HUMAN (790-1770): 6.65e-09: 63.5: 12.86		Q9H4D1_HUMAN (234-431): 1.43e-18: 92.7: 8.96
+	Hs
		943916 ANK2_HUMAN (790-1770): 6.65e-09: 63.5: 12.86		RIPK4_HUMAN (234-431): 3.46e-18: 91.5: 7.96
+	Hs
		920430 ANK2_HUMAN (790-1770): 6.65e-09: 63.5: 12.86		DAPK1_HUMAN (255-417): 7.8e-11: 68: 11.38
+	Hs
		177203 ANK2_HUMAN (790-1770): 6.65e-09: 63.5: 12.86		ANR28_HUMAN (26-383): 5.1e-09: 61.9: 9.05