HitPredict

Interactor 1: LTBP4 (Q8N2S1)
Latent-transforming growth factor beta-binding protein 4 (LTBP-4)
Gene: LTBP4

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EGF_CA~FXa_inhibition
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1624 Hs			1 273
+	Hs
		1324525 LTBP4_HUMAN (1-1624): 0: 636: 100.00		NELL1_HUMAN (82-180): 4.1e-26: 109: 36.63
+	Hs
		1324535 LTBP4_HUMAN (1-1624): 0: 636: 100.00		NELL2_HUMAN (82-176): 7.62e-26: 108: 34.65
+	Hs
		857580 NOTC1_HUMAN (502-1624): 2.77e-97: 351: 16.29		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Hs
		857407 NOTC1_HUMAN (502-1624): 2.77e-97: 351: 16.29		JAG1_HUMAN (66-168): 2.85e-10: 62.4: 28.57
+	Hs
		857370 NOTC1_HUMAN (502-1624): 2.77e-97: 351: 16.29		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57
+	Hs
		1459916 NOTC3_HUMAN (18-1052): 9.61e-67: 253: 16.53		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Mm
		1223430 NOTC3_MOUSE (923-1614): 5.7e-53: 208: 16.69		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Mm
		728041 NOTC4_MOUSE (16-843): 8.18e-45: 181: 12.01		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Hs
		1008030 NOTC3_HUMAN (18-1052): 9.61e-67: 253: 16.53		JAG1_HUMAN (66-168): 2.85e-10: 62.4: 28.57
+	Hs
		857591 NOTC3_HUMAN (18-1052): 9.61e-67: 253: 16.53		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57
+	Hs
		1047772 NOTC2_HUMAN (1-717): 1.51e-32: 140: 13.42		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Mm
		204911 NOTC2_MOUSE (1-713): 4.41e-34: 146: 12.20		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Hs
		572684 FBLN2_HUMAN (514-1010): 8.01e-43: 173: 35.15		NID1_HUMAN (60-271): 1.89e-16: 81: 16.46
+	Hs
		565099 FBLN2_HUMAN (514-1010): 8.01e-43: 173: 35.15		CSPG2_HUMAN (97-176): 3.7e-15: 77.5: 27.91
+	Hs
		317563 NOTC2_HUMAN (1-717): 1.51e-32: 140: 13.42		SLIT2_HUMAN (59-271): 1.73e-25: 107: 12.29
+	Hs
		452091 NOTC2_HUMAN (1-717): 1.51e-32: 140: 13.42		PROS_HUMAN (24-201): 7.76e-19: 87.9: 19.37
+	Hs
		1047591 NOTC2_HUMAN (1-717): 1.51e-32: 140: 13.42		NPNT_HUMAN (80-173): 3.93e-11: 64.8: 32.35
+	Hs
		1008015 NOTC2_HUMAN (1-717): 1.51e-32: 140: 13.42		JAG1_HUMAN (66-168): 2.85e-10: 62.4: 28.57
+	Hs
		857423 NOTC2_HUMAN (1-717): 1.51e-32: 140: 13.42		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57
+	Dm
		95089 E1JHA6_DROME (945-1624): 5.22e-32: 139: 11.93		NOTCH_DROME (68-172): 2.45e-09: 59.8: 22.32