HitPredict

Interactor 1: SYNE2 (Q8WXH0)
Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)
Gene: SYNE2

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005739 - mitochondrion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 6885 Hs			1 530
+	Hs
		404270 SYNE2_HUMAN (1-6885): 0: 1490: 100.00		GCR_HUMAN (3-495): 1.13e-103: 330: 22.64
+	Hs
		1367029 CLMN_HUMAN (18-283): 7.66e-50: 198: 47.06		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		1143215 PLEC_HUMAN (1306-3781): 6.32e-48: 195: 9.10		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		396148 PLEC_HUMAN (1306-3781): 6.32e-48: 195: 9.10		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		862681 UTRN_HUMAN (4629-6845): 4.74e-29: 132: 9.81		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		1040346 DYST_HUMAN (5367-6840): 5.03e-21: 105: 10.19		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		174790 SPTN2_HUMAN (3531-5279): 9.06e-16: 88.3: 8.43		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		395664 UTRN_HUMAN (4629-6845): 4.74e-29: 132: 9.81		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		1367596 MACF1_HUMAN (5906-6858): 3.06e-10: 70.2: 10.46		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		555734 ACTN1_HUMAN (4678-5164): 2.48e-10: 69.8: 10.92		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		395926 SPTB2_HUMAN (5537-6835): 6.21e-24: 115: 9.45		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		1061542 ACTN3_HUMAN (6421-6732): 3.91e-09: 65.9: 10.97		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		395953 DYST_HUMAN (5367-6840): 5.03e-21: 105: 10.19		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		343279 SPTN4_HUMAN (24-301): 1.87e-42: 176: 41.28		ERR2_HUMAN (69-499): 5.89e-109: 333: 31.57
+	Hs
		396550 SYNE1_HUMAN (5117-6861): 7.2e-16: 88.7: 9.96		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		397225 MACF1_HUMAN (5906-6858): 3.06e-10: 70.2: 10.46		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		395399 ACTN1_HUMAN (4678-5164): 2.48e-10: 69.8: 10.92		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		543601 MACF1_HUMAN (5906-6858): 3.06e-10: 70.2: 10.46		ERR1_HUMAN (85-497): 1.89e-112: 342: 35.65
+	Hs
		547417 DMD_HUMAN (5693-6857): 1.34e-12: 77.9: 11.20		HNF4A_HUMAN (94-502): 1.22e-107: 331: 23.30
+	Hs
		555672 ACTN1_HUMAN (4678-5164): 2.48e-10: 69.8: 10.92		NR1H3_HUMAN (65-499): 1.78e-104: 322: 20.97