HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27872092
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 1025
+	Hs
		136097 PLK4_HUMAN (1-970): 0: 1040: 100.00		MRCKA_HUMAN (418-981): 1.19e-30: 133: 12.40
+	Hs
		920052 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		MPRIP_HUMAN (1-1025): 9.69e-126: 410: 100.00
+	Hs
		270744 ROCK2_HUMAN (5-774): 1.36e-144: 467: 16.08		ROCK2_HUMAN (446-1018): 5.24e-17: 88.7: 11.81
+	Bt
		1177132 ROCK2_BOVIN (5-774): 8.03e-144: 465: 16.08		ROCK2_BOVIN (492-990): 3.24e-14: 79.7: 13.69
+	Hs
		270804 ROCK1_HUMAN (5-620): 1.22e-134: 439: 19.42		ROCK2_HUMAN (446-1018): 5.24e-17: 88.7: 11.81
+	Hs
		772782 ROCK1_HUMAN (5-620): 1.22e-134: 439: 19.42		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		1351377 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		DLG5_HUMAN (647-1019): 8.92e-54: 207: 21.61
+	Hs
		170199 AURKA_HUMAN (9-273): 3.29e-53: 193: 37.74		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		1391773 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		PKHA5_HUMAN (318-1019): 2.96e-36: 151: 13.24
+	Hs
		773248 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		MYH10_HUMAN (242-1024): 1.66e-21: 103: 8.45
+	Hs
		772956 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		920269 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		TARA_HUMAN (645-1023): 9.99e-10: 65.1: 12.98
+	Hs
		556888 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH1_HUMAN (515-1019): 1.69e-12: 74.4: 13.23
+	Hs
		776870 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH11_HUMAN (124-786): 5.18e-12: 72.4: 11.57
+	Hs
		556967 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH7_HUMAN (558-1009): 8.37e-12: 72.1: 10.92
+	Hs
		776845 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		MYH11_HUMAN (124-786): 5.18e-12: 72.4: 11.57
+	Hs
		1143233 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Hs
		1277768 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		MYH14_HUMAN (595-972): 3.71e-09: 63.1: 14.89