HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: MARCS (P29966)
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Gene: MARCKS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 332
+	Hs
		176240 FYN_HUMAN (556-721): 1.88e-31: 131: 20.69		SYNJ2_HUMAN (52-321): 7.17e-21: 95.7: 12.64
+	Hs
		176239 ABL1_HUMAN (532-725): 2.37e-30: 130: 21.54		SYNJ2_HUMAN (52-321): 7.17e-21: 95.7: 12.64
+	Hs
		319045 LYN_HUMAN (527-724): 1.29e-29: 125: 18.78		K0754_HUMAN (40-331): 3.65e-20: 93.8: 18.24
+	Hs
		440782 FYN_HUMAN (556-721): 1.88e-31: 131: 20.69		ASAP1_HUMAN (26-301): 8.91e-16: 80.3: 6.71
+	Hs
		840901 TEC_HUMAN (390-727): 3.86e-31: 131: 14.40		ASAP1_HUMAN (26-301): 8.91e-16: 80.3: 6.71
+	Hs
		362407 ABL1_HUMAN (532-725): 2.37e-30: 130: 21.54		ASAP1_HUMAN (26-301): 8.91e-16: 80.3: 6.71
+	Hs
		362149 ABL1_HUMAN (532-725): 2.37e-30: 130: 21.54		MUC1_HUMAN (25-331): 6.02e-15: 78: 14.01
+	Hs
		463001 YES_HUMAN (556-728): 4.11e-30: 127: 19.34		MARCS_HUMAN (1-322): 1.8e-16: 81: 100.00
+	Hs
		473483 HCK_HUMAN (551-724): 3.56e-30: 127: 22.53		ASAP1_HUMAN (26-301): 8.91e-16: 80.3: 6.71
+	Hs
		439935 LCK_HUMAN (520-724): 1.6e-30: 128: 21.03		MUC1_HUMAN (25-331): 6.02e-15: 78: 14.01
+	Hs
		463363 LYN_HUMAN (527-724): 1.29e-29: 125: 18.78		MARCS_HUMAN (1-322): 1.8e-16: 81: 100.00
+	Hs
		463316 LYN_HUMAN (527-724): 1.29e-29: 125: 18.78		MUC1_HUMAN (25-331): 6.02e-15: 78: 14.01
+	Hs
		557518 SRC_HUMAN (535-728): 2.75e-28: 122: 18.81		ASAP1_HUMAN (26-301): 8.91e-16: 80.3: 6.71
+	Hs
		557066 SRC_HUMAN (535-728): 2.75e-28: 122: 18.81		MUC1_HUMAN (25-331): 6.02e-15: 78: 14.01
+	Hs
		215893 LCK_HUMAN (520-724): 1.6e-30: 128: 21.03		SYNJ1_HUMAN (8-323): 1.4e-12: 70.6: 12.19
+	Hs
		176248 P85A_HUMAN (606-721): 3.8e-21: 100: 28.81		SYNJ2_HUMAN (52-321): 7.17e-21: 95.7: 12.64
+	Hs
		440773 FYN_HUMAN (556-721): 1.88e-31: 131: 20.69		MAGL2_HUMAN (3-326): 1.59e-10: 64.5: 9.31
+	Hs
		440813 FYN_HUMAN (556-721): 1.88e-31: 131: 20.69		MYO16_HUMAN (49-328): 2.7e-10: 63.7: 9.82
+	Hs
		913671 VAV2_HUMAN (561-717): 1.36e-31: 134: 21.18		TITIN_HUMAN (3-293): 7.73e-09: 59.5: 13.74
+	Hs
		463714 LYN_HUMAN (527-724): 1.29e-29: 125: 18.78		PRAM_HUMAN (4-329): 1.54e-10: 64.1: 7.98