HitPredict

Interactor 1: STAM1 (O01498)
Signal transducing adapter molecule 1 (STAM-1) (Prion-like-(Q/N-rich) domain-bearing protein 19)
Gene: stam-1

Interactor 2: Q17796 (Q17796)
Hepatocyte growth factor-regulated tyrosine kinase substrate
Gene: hgrs-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.900

Property	Details
Experiments	23549480, 21193406, 23818590, 11731503
Identification Methods	two hybrid, affinity chromatography technology, biochemical
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	FYVE~VHS, VHS~VHS
Common GO terms	GO:0005769 - early endosome GO:0033565 - ESCRT-0 complex GO:0043130 - ubiquitin binding GO:0097499 - protein localization to non-motile cilium
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 457 Ce			1 729
+	Hs
		160122 STAM1_HUMAN (7-456): 4.54e-87: 277: 30.11		HGS_HUMAN (2-693): 1.44e-135: 420: 33.86
+	Hs
		159809 STAM2_HUMAN (7-456): 6.93e-86: 274: 27.92		HGS_HUMAN (2-693): 1.44e-135: 420: 33.86
+	Mm
		292346 STAM2_MOUSE (7-455): 1.41e-87: 278: 27.65		HGS_MOUSE (2-693): 1.16e-131: 409: 33.43
+	Ce
		1089151 Q17796_CAEEL (9-148): 1.44e-46: 173: 26.43		Q17796_CAEEL (1-729): 7.14e-159: 478: 100.00
+	Hs
		159801 TOM1_HUMAN (5-361): 4.54e-53: 187: 17.79		HGS_HUMAN (2-693): 1.44e-135: 420: 33.86
+	Hs
		159808 TM1L1_HUMAN (2-457): 1.21e-45: 166: 14.78		HGS_HUMAN (2-693): 1.44e-135: 420: 33.86
+	Hs
		160223 GGA2_HUMAN (8-456): 7.15e-44: 164: 14.71		HGS_HUMAN (2-693): 1.44e-135: 420: 33.86
+	Dm
		1280459 Q9XTL2_DROME (9-456): 8.77e-67: 228: 29.13		HRS_DROME (1-729): 7.19e-100: 326: 30.65
+	Hs
		277104 STAM1_HUMAN (7-456): 4.54e-87: 277: 30.11		STAM2_HUMAN (2-146): 1.48e-46: 175: 29.66
+	Sc
		753628 HSE1_YEAST (6-449): 3.27e-57: 197: 19.60		VPS27_YEAST (3-663): 5.91e-72: 248: 17.16
+	Ce
		136427 STAM1_CAEEL (1-457): 2.84e-88: 278: 100.00		STAM1_CAEEL (3-152): 1.94e-39: 153: 25.66
+	Sc
		772382 VPS27_YEAST (7-457): 1.63e-44: 166: 15.59		VPS27_YEAST (3-663): 5.91e-72: 248: 17.16
+	Hs
		276978 STAM2_HUMAN (7-456): 6.93e-86: 274: 27.92		ZFYV9_HUMAN (103-253): 2.49e-30: 130: 21.94
+	Hs
		241128 TOM1_HUMAN (5-361): 4.54e-53: 187: 17.79		TM1L1_HUMAN (1-474): 6.36e-60: 211: 11.67
+	Hs
		1348858 GGA2_HUMAN (8-456): 7.15e-44: 164: 14.71		GGA3_HUMAN (4-633): 4.18e-59: 214: 11.53
+	Hs
		1356188 GGA2_HUMAN (8-456): 7.15e-44: 164: 14.71		GGA2_HUMAN (2-429): 3.53e-53: 196: 10.35
+	Hs
		277083 STAM2_HUMAN (7-456): 6.93e-86: 274: 27.92		ZFY16_HUMAN (146-214): 7.47e-11: 68.2: 41.67
+	Hs
		241175 TOM1_HUMAN (5-361): 4.54e-53: 187: 17.79		ZFY16_HUMAN (146-214): 7.47e-11: 68.2: 41.67