HitPredict

Interactor 1: MEIS1 (O00470)
Homeobox protein Meis1
Gene: MEIS1

Interactor 2: TLX3 (O43711)
T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)
Gene: TLX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	20211142
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045665 - negative regulation of neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 291
+	Mm
		915926 MEIS1_MOUSE (1-390): 7.94e-139: 402: 99.74		PDX1_MOUSE (63-246): 5.26e-40: 142: 26.56
+	Hs
		137123 MEIS1_HUMAN (1-390): 7.68e-139: 402: 100.00		TLX1_HUMAN (1-290): 1.1e-38: 140: 53.98
+	Mm
		1222051 MEIS1_MOUSE (1-390): 7.94e-139: 402: 99.74		Q9QX99_MOUSE (1-290): 6.05e-38: 138: 52.92
+	Mm
		478348 MEIS1_MOUSE (1-390): 7.94e-139: 402: 99.74		HXA5_MOUSE (31-237): 4.94e-36: 131: 18.81
+	Hs
		137115 MEIS1_HUMAN (1-390): 7.68e-139: 402: 100.00		TLX2_HUMAN (4-290): 2.38e-35: 130: 58.89
+	Hs
		137127 MEIS1_HUMAN (1-390): 7.68e-139: 402: 100.00		EMX2_HUMAN (9-255): 1.46e-30: 116: 26.40
+	Mm
		724898 MEIS1_MOUSE (1-390): 7.94e-139: 402: 99.74		HXA2_MOUSE (50-235): 1.35e-29: 116: 24.60
+	Hs
		163413 MEIS2_HUMAN (1-385): 2.85e-116: 348: 80.81		TLX1_HUMAN (1-290): 1.1e-38: 140: 53.98
+	Mm
		989223 MEIS2_MOUSE (1-385): 7.03e-117: 350: 80.81		PAX6_MOUSE (36-289): 3.28e-30: 119: 16.73
+	Mm
		1021237 MEIS2_MOUSE (1-385): 7.03e-117: 350: 80.81		EMX1_MOUSE (165-238): 3.76e-12: 66.6: 47.30
+	Dm
		235202 HTH_DROME (1-389): 3.22e-87: 274: 47.00		UBX_DROME (27-230): 2.28e-30: 119: 22.49
+	Hs
		184766 PKNX1_HUMAN (13-379): 5.46e-82: 259: 35.08		SHOX_HUMAN (112-257): 4.85e-33: 124: 19.86
+	Mm
		479042 PKNX2_MOUSE (1-376): 1.75e-80: 256: 35.47		HXA6_MOUSE (22-244): 3.94e-33: 123: 17.86
+	Hs
		685140 PKNX1_HUMAN (13-379): 5.46e-82: 259: 35.08		PAX6_HUMAN (36-289): 3.28e-30: 119: 16.73
+	Hs
		725217 PBX3_HUMAN (6-390): 8.82e-52: 180: 15.71		TLX1_HUMAN (1-290): 1.1e-38: 140: 53.98
+	Mm
		204668 PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71		HXD4_MOUSE (36-226): 5.29e-35: 128: 25.26
+	Mm
		204665 PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71		HXA6_MOUSE (22-244): 3.94e-33: 123: 17.86
+	Mm
		204664 PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71		HXB5_MOUSE (45-241): 9.36e-32: 120: 26.40
+	Mm
		204669 PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71		HXC6_MOUSE (127-224): 8.42e-32: 119: 31.63
+	Hs
		478300 PBX4_HUMAN (43-363): 2.16e-52: 180: 16.81		HXD4_HUMAN (16-256): 1.19e-30: 117: 20.75