HitPredict

Interactor 1: DVL3 (Q92997)
Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)
Gene: DVL3

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	20412773
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 716 Hs			1 400
+	Hs
		159396 DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Hs
		159842 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Hs
		1371432 DVL3_HUMAN (1-716): 6.43e-168: 501: 100.00		WWP1_HUMAN (3-386): 5.13e-64: 222: 13.86
+	Hs
		1371403 DVL3_HUMAN (1-716): 6.43e-168: 501: 100.00		ITCH_HUMAN (37-356): 2.66e-60: 211: 14.83
+	Hs
		159397 DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38		WWP1_HUMAN (3-386): 5.13e-64: 222: 13.86
+	Hs
		159392 DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38		ITCH_HUMAN (37-356): 2.66e-60: 211: 14.83
+	Hs
		131571 DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38		WWP2_HUMAN (3-220): 6.69e-59: 207: 19.46
+	Hs
		159368 DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38		HECW1_HUMAN (14-327): 1.33e-53: 193: 14.29
+	Hs
		159845 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		WWP1_HUMAN (3-386): 5.13e-64: 222: 13.86
+	Hs
		159802 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		ITCH_HUMAN (37-356): 2.66e-60: 211: 14.83
+	Hs
		131572 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		WWP2_HUMAN (3-220): 6.69e-59: 207: 19.46
+	Hs
		1371458 DVL3_HUMAN (1-716): 6.43e-168: 501: 100.00		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Mm
		1221615 DVL2_MOUSE (3-716): 1.06e-129: 403: 63.37		SMUF1_MOUSE (81-321): 5.33e-51: 184: 18.70
+	Mm
		59023 DVL1_MOUSE (1-716): 1.9e-150: 455: 62.55		SMUF2_MOUSE (156-326): 1.19e-24: 108: 11.40
+	Hs
		159326 DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38		NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00
+	Hs
		159402 DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Mm
		59029 DVL2_MOUSE (3-716): 1.06e-129: 403: 63.37		SMUF2_MOUSE (156-326): 1.19e-24: 108: 11.40
+	Hs
		159863 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		SMUF2_HUMAN (156-326): 4.18e-25: 109: 11.92
+	Hs
		159556 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00
+	Hs
		159809 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		NED4L_HUMAN (164-352): 3.04e-13: 73.5: 13.20