HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	26871637, 16189514, 25910212, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid bait and prey pooling approach, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 430
+	Hs
		159796 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT86_HUMAN (12-391): 3.53e-91: 285: 24.87
+	Hs
		160003 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94
+	Hs
		159833 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58
+	Hs
		159853 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64
+	Hs
		159854 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K1C16_HUMAN (77-404): 2.34e-87: 275: 49.85
+	Hs
		159882 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K1C15_HUMAN (79-420): 2.92e-87: 275: 48.28
+	Hs
		159999 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KT33B_HUMAN (79-385): 4.54e-87: 272: 47.40
+	Hs
		159867 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K1C13_HUMAN (57-389): 1.38e-85: 270: 48.96
+	Hs
		160204 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT82_HUMAN (12-391): 1.15e-84: 269: 25.98
+	Hs
		159824 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K2C75_HUMAN (4-400): 1.01e-83: 268: 24.50
+	Hs
		159813 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT34_HUMAN (79-385): 1.5e-82: 260: 44.81
+	Hs
		160021 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K1C24_HUMAN (80-388): 4.27e-81: 260: 50.48
+	Hs
		160121 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT35_HUMAN (4-391): 7.57e-74: 240: 40.87
+	Hs
		159834 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		K2C6A_HUMAN (45-406): 1.72e-71: 236: 23.90
+	Hs
		159814 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		KRT36_HUMAN (4-391): 3.76e-71: 233: 40.87
+	Hs
		3235 A0A0S2Z4Q4_HUMAN (1-703): 3.76e-49: 186: 40.68		K1C13_HUMAN (57-389): 1.38e-85: 270: 48.96
+	Hs
		3234 A0A0S2Z4Q4_HUMAN (1-703): 3.76e-49: 186: 40.68		K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00