HitPredict

Interactor 1: NLRP1 (Q9C000)
NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]
Gene: NLRP1

Interactor 2: NLRP1 (Q9C000)
NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]
Gene: NLRP1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 21252346
Identification Methods anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, FIIND~FIIND, LRR_1~LRR_1, LRR_1~LRR_6, LRR_1~PYRIN, LRR_6~LRR_6, LRR_6~NACHT, NACHT~NACHT, NACHT~NLRC4_HD2, NACHT~NOD2_WH, NLRC4_HD2~NOD2_WH, PYRIN~PYRIN
Common GO terms GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway
GO:0003690 - double-stranded DNA binding
GO:0003725 - double-stranded RNA binding
GO:0005524 - ATP binding
and 34 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1473
Hs

1 1473
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025