Protein: Q4LE69
1-phosphatidylinositol 4-kinase (EC 2.7.1.67)

Gene: Q4LE69, PIK4CA
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q4LE69

Gene Ontology (top 5):
GO:0004430 - 1-phosphatidylinositol 4-kinase activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0016310 - phosphorylation
GO:0046854 - phosphatidylinositol phosphate biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

350216

RASK
GTPase KRas

3

20

High-throughput

0.827

High

411746

LCK
Tyrosine-protein kinase Lck

2

7

Small-scale

0.768

High

349368

RASH
GTPase HRas

2

20

High-throughput

0.754

High

915720

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

964110

CD83
CD83 antigen

2

1

High-throughput

0.754

High

1117761

TTC7B
Tetratricopeptide repeat protein 7B

2

4

High-throughput

0.754

High

1117805

PD1L1
Programmed cell death 1 ligand 1

2

2

Small-scale

0.754

High

205472

TGON2
Trans-Golgi network integral membrane protein 2

3

6

High-throughput

0.640

High

1117814

CAH14
Carbonic anhydrase 14

3

2

High-throughput

0.640

High

1117804

STRN4
Striatin-4

1

4

High-throughput

0.621

High

120471

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

348701

RASN
GTPase NRas

1

20

High-throughput

0.618

High

433799

LYN
Tyrosine-protein kinase Lyn

1

8

High-throughput

0.618

High

436341

RHOC
Rho-related GTP-binding protein RhoC

1

16

High-throughput

0.618

High

545417

RAC2
Ras-related C3 botulinum toxin substrate 2

1

17

High-throughput

0.618

High

564555

RHOQ
Rho-related GTP-binding protein RhoQ

1

19

High-throughput

0.618

High

771192

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

1

High-throughput

0.618

High

844963

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.618

High

845516

RAB9A
Ras-related protein Rab-9A

1

17

High-throughput

0.618

High

852505

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

892405

RAC3
Ras-related C3 botulinum toxin substrate 3

1

18

High-throughput

0.618

High

894084

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

900539

RHOA
Transforming protein RhoA

1

18

High-throughput

0.618

High

901172

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

925325

RAC1
Ras-related C3 botulinum toxin substrate 1

1

18

High-throughput

0.618

High

951044

RHOG
Rho-related GTP-binding protein RhoG

1

17

High-throughput

0.618

High

1070222

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.618

High

1076603

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1078211

CD226
CD226 antigen

1

3

High-throughput

0.618

High

1117747

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.618

High

1117760

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1117780

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1117787

DNJC7
DnaJ homolog subfamily C member 7

1

3

High-throughput

0.618

High

1117795

RHOJ
Rho-related GTP-binding protein RhoJ

1

19

High-throughput

0.618

High

1117801

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1117813

TTC7A
Tetratricopeptide repeat protein 7A

1

3

High-throughput

0.618

High

488248

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

2

High-throughput

0.584

High

591218

ACM3
Muscarinic acetylcholine receptor M3

2

5

High-throughput

0.584

High

723045

OPRM
Mu-type opioid receptor

2

7

High-throughput

0.584

High

824703

NPY2R
Neuropeptide Y receptor type 2

2

8

High-throughput

0.584

High

912936

ARF6
ADP-ribosylation factor 6

2

2

High-throughput

0.584

High

1043029

CUL4A
Cullin-4A

2

1

High-throughput

0.584

High

1117789

HYCCI
Hyccin

2

3

High-throughput

0.584

High

895109

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.553

High

914106

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.553

High

1117768

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.553

High

1117815

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.553

High

1117819

TRRAP
Transformation/transcription domain-associated protein

1

5

High-throughput

0.553

High

1117770

F174A
Membrane protein FAM174A

2

1

High-throughput

0.533

High

825704

MTR1B
Melatonin receptor type 1B

1

7

High-throughput

0.501

High

1117820

SNX9
Sorting nexin-9

1

1

Small-scale

0.501

High

779524

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

1117809

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

1117800

RM44
Large ribosomal subunit protein mL44

1

1

High-throughput

0.481

High

123614

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.479

High

126596

P2Y10
Putative P2Y purinoceptor 10

1

18

High-throughput

0.479

High

172016

GP182
G-protein coupled receptor 182

1

12

High-throughput

0.479

High

178567

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

233490

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

271869

SPB7
Serpin B7

1

11

High-throughput

0.479

High

277308

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.479

High

279579

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

283195

RGS20
Regulator of G-protein signaling 20

1

1

High-throughput

0.479

High

304966

DUS14
Dual specificity protein phosphatase 14

1

3

High-throughput

0.479

High

322712

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

328334

S1PR4
Sphingosine 1-phosphate receptor 4

1

9

High-throughput

0.479

High

346949

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

359026

CRYAB
Alpha-crystallin B chain

1

2

High-throughput

0.479

High

363197

FINC
Fibronectin

1

1

High-throughput

0.479

High

369736

ESR1
Estrogen receptor

1

9

High-throughput

0.479

High

384947

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.479

High

397035

PAI2
Plasminogen activator inhibitor 2

1

11

High-throughput

0.479

High

416443

S10A9
Protein S100-A9

1

8

High-throughput

0.479

High

428587

INVO
Involucrin

1

7

High-throughput

0.479

High

435660

IGF1R
Insulin-like growth factor 1 receptor

1

15

High-throughput

0.479

High

517807

NFH
Neurofilament heavy polypeptide

1

9

High-throughput

0.479

High

521975

CADH1
Cadherin-1

1

5

High-throughput

0.479

High

542344

PLAK
Junction plakoglobin

1

6

High-throughput

0.479

High

547085

EZRI
Ezrin

1

2

High-throughput

0.479

High

556510

LEUK
Leukosialin

1

1

High-throughput

0.479

High

557550

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

3

High-throughput

0.479

High

567088

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

572639

VGFR1
Vascular endothelial growth factor receptor 1

1

12

High-throughput

0.479

High

581763

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.479

High

598949

FPR1
fMet-Leu-Phe receptor

1

10

High-throughput

0.479

High

609327

FGFR3
Fibroblast growth factor receptor 3

1

17

High-throughput

0.479

High

611253

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.479

High

617212

LORI
Loricrin

1

1

High-throughput

0.479

High

665613

EPHB2
Ephrin type-B receptor 2

1

5

High-throughput

0.479

High

670055

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

713098

SDC2
Syndecan-2

1

1

High-throughput

0.479

High

714664

CNR2
Cannabinoid receptor 2

1

5

Small-scale

0.479

High

723312

APJ
Apelin receptor

1

6

High-throughput

0.479

High

738220

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

11

High-throughput

0.479

High

772875

ADH7
All-trans-retinol dehydrogenase [NAD(+)] ADH7

1

2

High-throughput

0.479

High

803564

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.479

High

819156

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

3

High-throughput

0.479

High

823413

PAXI
Paxillin

1

1

High-throughput

0.479

High

863774

LIMK1
LIM domain kinase 1

1

8

High-throughput

0.479

High

876131

PAR2
Proteinase-activated receptor 2

1

17

High-throughput

0.479

High

904645

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

970784

DSG1
Desmoglein-1

1

7

High-throughput

0.479

High

971022

DSC2
Desmocollin-2

1

7

High-throughput

0.479

High

982077

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1034879

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

1041706

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1049759

EFR3A
Protein EFR3 homolog A

1

6

High-throughput

0.479

High

1060994

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

Small-scale

0.479

High

1074529

CDSN
Corneodesmosin

1

2

High-throughput

0.479

High

1108689

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.479

High

1117748

DJC21
DnaJ homolog subfamily C member 21

1

3

High-throughput

0.479

High

1117749

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

1

High-throughput

0.479

High

1117750

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.479

High

1117752

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1117758

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1117759

FBX50
F-box only protein 50

1

2

High-throughput

0.479

High

1117762

P2RY8
P2Y purinoceptor 8

1

16

High-throughput

0.479

High

1117763

SPA12
Serpin A12

1

11

High-throughput

0.479

High

1117764

HYCC2
Hyccin 2

1

3

High-throughput

0.479

High

1117766

ARRD4
Arrestin domain-containing protein 4

1

13

High-throughput

0.479

High

1117767

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

2

High-throughput

0.479

High

1117769

DNJB8
DnaJ homolog subfamily B member 8

1

5

High-throughput

0.479

High

1117771

PKR1
Prokineticin receptor 1

1

9

High-throughput

0.479

High

1117775

EVPL
Envoplakin

1

12

High-throughput

0.479

High

1117776

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

5

High-throughput

0.479

High

1117778

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.479

High

1117779

ARRD3
Arrestin domain-containing protein 3

1

13

High-throughput

0.479

High

1117784

OPALI
Opalin

1

1

High-throughput

0.479

High

1117785

TESK2
Dual specificity testis-specific protein kinase 2

1

5

High-throughput

0.479

High

1117786

SORT
Sortilin

1

2

High-throughput

0.479

High

1117790

CD244
Natural killer cell receptor 2B4

1

2

High-throughput

0.479

High

1117792

RNAS7
Ribonuclease 7

1

2

High-throughput

0.479

High

1117793

TXNIP
Thioredoxin-interacting protein

1

13

High-throughput

0.479

High

1117794

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1117796

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1117797

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1117802

E41LA
Band 4.1-like protein 4A

1

2

High-throughput

0.479

High

1117806

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

10

High-throughput

0.479

High

1117807

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

2

High-throughput

0.479

High

1117808

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1117810

SPB13
Serpin B13

1

8

High-throughput

0.479

High

1117816

EFR3B
Protein EFR3 homolog B

1

6

High-throughput

0.479

High

1117817

GPR55
G-protein coupled receptor 55

1

20

High-throughput

0.479

High

1117821

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.479

High

530678

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

818113

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

1084027

OCLN
Occludin

1

0

High-throughput

0.458

High

1117751

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1117756

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1117791

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

533601

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.439

High

1117798

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.439

High

50159

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.437

High

72299

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

3

High-throughput

0.437

High

132490

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

235890

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.437

High

305476

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

588422

TYPH
Thymidine phosphorylase

1

2

High-throughput

0.437

High

596287

FILA
Filaggrin

1

9

High-throughput

0.437

High

645973

CRBB3
Beta-crystallin B3

1

2

High-throughput

0.437

High

648516

CALL3
Calmodulin-like protein 3

1

2

High-throughput

0.437

High

787737

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.437

High

801180

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.437

High

819416

GSH0
Glutamate--cysteine ligase regulatory subunit

1

4

High-throughput

0.437

High

836309

KLK7
Kallikrein-7

1

5

High-throughput

0.437

High

885924

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.437

High

902322

COPZ1
Coatomer subunit zeta-1

1

3

High-throughput

0.437

High

957410

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.437

High

1017141

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.437

High

1021298

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.437

High

1034066

TCOF
Treacle protein

1

3

Small-scale

0.437

High

1066209

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.437

High

1069360

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.437

High

1081057

CCDC6
Coiled-coil domain-containing protein 6

1

12

High-throughput

0.437

High

1083740

ECM1
Extracellular matrix protein 1

1

2

High-throughput

0.437

High

1100044

INF2
Inverted formin-2

1

2

High-throughput

0.437

High

1117753

PLBL1
Phospholipase B-like 1

1

2

High-throughput

0.437

High

1117754

PKN3
Serine/threonine-protein kinase N3

1

6

High-throughput

0.437

High

1117755

SBSN
Suprabasin

1

2

High-throughput

0.437

High

1117765

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.437

High

1117772

POF1B
Protein POF1B

1

2

High-throughput

0.437

High

1117773

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.437

High

1117774

ESR2
Estrogen receptor beta

1

9

High-throughput

0.437

High

1117781

SNX27
Sorting nexin-27

1

2

High-throughput

0.437

High

1117782

CB050
Uncharacterized protein C2orf50

1

1

High-throughput

0.437

High

1117788

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.437

High

1117799

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.437

High

1117803

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.437

High

1117811

ANC2
Anaphase-promoting complex subunit 2

1

3

High-throughput

0.437

High

1117812

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.437

High

1117818

KLK5
Kallikrein-5

1

5

High-throughput

0.437

High

1117822

NPTN
Neuroplastin

1

2

High-throughput

0.437

High

50392

NDUF8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

1

0

High-throughput

0.249

Low

118331

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

130517

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

1101079

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1117757

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1117777

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1117783

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024