Protein: ASC
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)

Gene: ASC, PYCARD
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q9ULZ3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001773 - myeloid dendritic cell activation
GO:0002020 - protease binding
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1399406

NLRP3
NACHT, LRR and PYD domains-containing protein 3

25

18

Small-scale

0.989

High

712900

CASP1
Caspase-1

13

16

Small-scale

0.978

High

1461872

ASC
Apoptosis-associated speck-like protein containing a CARD

11

18

Small-scale

0.977

High

166206

AIM2
Interferon-inducible protein AIM2

6

2

Small-scale

0.956

High

194793

MEFV
Pyrin

6

9

Small-scale

0.954

High

1446611

NLRC4
NLR family CARD domain-containing protein 4

6

20

Small-scale

0.931

High

1360270

PYDC1
Pyrin domain-containing protein 1

4

17

Small-scale

0.879

High

1161754

IF16
Gamma-interferon-inducible protein 16

3

2

Small-scale

0.827

High

1420419

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

19

Small-scale

0.789

High

1451613

NALP2
NACHT, LRR and PYD domains-containing protein 2

2

18

Small-scale

0.776

High

1108277

SQSTM
Sequestosome-1

5

4

Small-scale

0.717

High

1060141

BAX
Apoptosis regulator BAX

1

2

Small-scale

0.696

High

1132467

CASP8
Caspase-8

5

16

Small-scale

0.695

High

1201304

PYDC2
Pyrin domain-containing protein 2

1

17

Small-scale

0.683

High

1109680

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.665

High

188727

BIRC5
Baculoviral IAP repeat-containing protein 5

2

1

High-throughput

0.628

High

1113023

CUL2
Cullin-2

2

7

High-throughput

0.628

High

1258251

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

2

3

Small-scale

0.624

High

214468

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

1

Small-scale

0.618

High

947311

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

20

Small-scale

0.618

High

1292009

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

17

Small-scale

0.618

High

943457

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

2

0

High-throughput

0.602

High

1400525

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

1421073

ZY11B
Protein zyg-11 homolog B

2

0

High-throughput

0.602

High

1461878

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.602

High

531175

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.582

High

1461880

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

Small-scale

0.578

High

1431527

CARD9
Caspase recruitment domain-containing protein 9

1

1

Small-scale

0.575

High

849271

KSYK
Tyrosine-protein kinase SYK

1

6

Small-scale

0.568

High

1395492

ZFP91
E3 ubiquitin-protein ligase ZFP91

2

0

Small-scale

0.559

High

167995

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

11

Small-scale

0.554

High

177959

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

11

Small-scale

0.554

High

137291

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.549

High

353909

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.546

High

123874

MYO1C
Unconventional myosin-Ic

1

2

Small-scale

0.536

High

220816

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

Small-scale

0.536

High

714518

PML
Protein PML

1

6

Small-scale

0.536

High

733469

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

820546

IL6RB
Interleukin-6 receptor subunit beta

1

1

Small-scale

0.536

High

1010790

SSBP2
Single-stranded DNA-binding protein 2

1

1

High-throughput

0.536

High

1126784

BECN1
Beclin-1

1

8

Small-scale

0.536

High

1325972

FSTL5
Follistatin-related protein 5

1

2

Small-scale

0.536

High

1333025

F184A
Protein FAM184A

1

5

Small-scale

0.536

High

1416889

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

3

Small-scale

0.536

High

1448422

TSH2
Teashirt homolog 2

1

1

Small-scale

0.536

High

1453755

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

High-throughput

0.536

High

1461874

CP131
Centrosomal protein of 131 kDa

1

1

Small-scale

0.536

High

1461876

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.536

High

345130

RIGI
Antiviral innate immune response receptor RIG-I

1

4

Small-scale

0.515

High

1096516

PAK1
Serine/threonine-protein kinase PAK 1

1

2

High-throughput

0.515

High

1273881

NLRC3
NLR family CARD domain-containing protein 3

1

18

Small-scale

0.515

High

141771

CCL21
C-C motif chemokine 21

1

0

High-throughput

0.513

High

186457

INP4B
Inositol polyphosphate 4-phosphatase type II

1

0

Small-scale

0.513

High

210798

KLK10
Kallikrein-10

1

0

High-throughput

0.513

High

602852

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

755818

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.513

High

892646

DNLI3
DNA ligase 3

1

0

Small-scale

0.513

High

943160

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

945330

NU107
Nuclear pore complex protein Nup107

1

0

Small-scale

0.513

High

995505

TPM4
Tropomyosin alpha-4 chain

1

0

Small-scale

0.513

High

1023913

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1118392

BMPR2
Bone morphogenetic protein receptor type-2

1

0

Small-scale

0.513

High

1314291

DRC7
Dynein regulatory complex subunit 7

1

0

Small-scale

0.513

High

1335549

NF2IP
NFATC2-interacting protein

1

0

High-throughput

0.513

High

1408255

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.513

High

1365943

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

1

Small-scale

0.501

High

1461877

MAN1
Inner nuclear membrane protein Man1

1

1

Small-scale

0.489

High

50004

IRGM
Immunity-related GTPase family M protein

1

1

Small-scale

0.479

High

539913

RALB
Ras-related protein Ral-B

1

2

Small-scale

0.479

High

631557

RAB5A
Ras-related protein Rab-5A

1

3

Small-scale

0.479

High

799573

BRCA1
Breast cancer type 1 susceptibility protein

1

6

Small-scale

0.479

High

1095007

TRAF3
TNF receptor-associated factor 3

1

10

Small-scale

0.479

High

1100533

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

1161436

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.479

High

1351897

NEK7
Serine/threonine-protein kinase Nek7

1

4

Small-scale

0.479

High

1367578

ESR2
Estrogen receptor beta

1

2

Small-scale

0.479

High

1390446

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.479

High

1433239

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

Small-scale

0.479

High

1451789

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

Small-scale

0.479

High

1461873

APC10
Anaphase-promoting complex subunit 10

1

1

Small-scale

0.479

High

1461879

TRAF6
TNF receptor-associated factor 6

1

12

Small-scale

0.479

High

414840

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

335200

ARI2
E3 ubiquitin-protein ligase ARIH2

1

4

Small-scale

0.445

High

1458962

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

2

Small-scale

0.445

High

1461881

NEMO
NF-kappa-B essential modulator

1

2

Small-scale

0.445

High

378583

IL1B
Interleukin-1 beta

1

3

Small-scale

0.428

High

325366

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

1022102

ENTK
Enteropeptidase

1

0

Small-scale

0.279

Low

1181358

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1337600

ARMC2
Armadillo repeat-containing protein 2

1

0

Small-scale

0.279

Low

1380566

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

1451710

DJC28
DnaJ homolog subfamily C member 28

1

0

Small-scale

0.279

Low

1409913

ZFY21
Zinc finger FYVE domain-containing protein 21

1

0

Small-scale

0.261

Low

1461875

POK19
Endogenous retrovirus group K member 19 Pol protein

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025