HitPredict - High confidence protein-protein interactions

Interactor 1: SIR5 (Q9NXA8)
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
Gene: SIRT5

Interactor 2: SIR5 (Q9NXA8)
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
Gene: SIRT5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SIR2~SIR2
Common GO terms	GO:0002931 - response to ischemia GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0005758 - mitochondrial intermembrane space and 20 others more... GO:0005759 - mitochondrial matrix GO:0005829 - cytosol GO:0006476 - protein deacetylation GO:0007005 - mitochondrion organization GO:0008270 - zinc ion binding GO:0010566 - regulation of ketone biosynthetic process GO:0010667 - negative regulation of cardiac muscle cell apoptotic process GO:0017136 - histone deacetylase activity, NAD-dependent GO:0031667 - response to nutrient levels GO:0034979 - NAD-dependent protein lysine deacetylase activity GO:0036046 - protein demalonylation GO:0036047 - peptidyl-lysine demalonylation GO:0036048 - protein desuccinylation GO:0036049 - peptidyl-lysine desuccinylation GO:0036054 - protein-malonyllysine demalonylase activity GO:0036055 - protein-succinyllysine desuccinylase activity GO:0061697 - protein-glutaryllysine deglutarylase activity GO:0061698 - protein deglutarylation GO:0070403 - NAD+ binding GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1	310
Hs

1	310

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Last updated: 11Aug2025