HitPredict

Interactor 1: Q9V455 (Q9V455)
Importin subunit alpha
Gene: Kap-alpha3

Interactor 2: Q9VN44 (Q9VN44)
FI07923p (Karyopherin beta 3, isoform A) (Karyopherin beta 3, isoform B)
Gene: Karybeta3

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HEAT_EZ~IBB
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding GO:0061608 - nuclear import signal receptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 514 Dm			1 1105
+	Hs
		133985 IMA5_HUMAN (4-514): 9.79e-138: 410: 44.65		IPO5_HUMAN (4-1098): 0: 696: 51.78
+	Ce
		1167005 IMA3_CAEEL (4-514): 2.7e-147: 433: 59.73		Q9N5V3_CAEEL (4-1079): 2.53e-171: 534: 33.61
+	Sc
		734720 IMA1_YEAST (5-514): 2.67e-141: 419: 42.59		IMB3_YEAST (7-1076): 1.37e-123: 407: 29.88
+	Sc
		817937 IMA1_YEAST (5-514): 2.67e-141: 419: 42.59		IMB4_YEAST (4-1104): 3.82e-108: 366: 18.44
+	Sp
		151868 IMA2_SCHPO (2-514): 5.19e-141: 418: 42.78		IMB1_SCHPO (10-812): 2.47e-91: 314: 18.46
+	Hs
		142598 IMA3_HUMAN (3-514): 1.04e-155: 455: 65.57		TNPO1_HUMAN (253-1096): 3.12e-67: 246: 12.18
+	Hs
		911035 IMA1_HUMAN (2-514): 1.22e-147: 435: 48.29		TNPO1_HUMAN (253-1096): 3.12e-67: 246: 12.18
+	Sc
		1039045 IMA1_YEAST (5-514): 2.67e-141: 419: 42.59		IMB1_YEAST (6-705): 1.09e-64: 238: 15.89
+	At
		1379674 IMPA1_ARATH (1-514): 2.22e-159: 465: 42.86		IMB1_ARATH (225-1070): 1.22e-38: 158: 11.59
+	Dm
		197653 Q9V455_DROME (1-514): 2.31e-164: 477: 100.00		IMB_DROME (215-1068): 1.31e-32: 138: 11.25
+	At
		102360 IMPA2_ARATH (1-514): 6.53e-154: 451: 42.06		IMB1_ARATH (225-1070): 1.22e-38: 158: 11.59
+	Mm
		911179 IMA1_MOUSE (2-514): 3.15e-145: 429: 48.00		IMB1_MOUSE (218-1068): 5.22e-38: 156: 11.52
+	Hs
		910972 IMA1_HUMAN (2-514): 1.22e-147: 435: 48.29		CAND1_HUMAN (130-1063): 9.23e-25: 114: 9.20
+	Hs
		253653 IMA7_HUMAN (4-514): 7.61e-147: 433: 44.70		CAND1_HUMAN (130-1063): 9.23e-25: 114: 9.20
+	Sp
		152746 IMA2_SCHPO (2-514): 5.19e-141: 418: 42.78		IMB2_SCHPO (358-1096): 1.51e-22: 106: 14.08
+	Hs
		138688 IMA4_HUMAN (5-514): 6.23e-157: 458: 67.38		IMB1_HUMAN (539-1081): 9.24e-10: 65: 11.11
+	Hs
		142553 IMA3_HUMAN (3-514): 1.04e-155: 455: 65.57		IMB1_HUMAN (539-1081): 9.24e-10: 65: 11.11
+	Hs
		910902 IMA1_HUMAN (2-514): 1.22e-147: 435: 48.29		IMB1_HUMAN (539-1081): 9.24e-10: 65: 11.11
+	Hs
		253632 IMA7_HUMAN (4-514): 7.61e-147: 433: 44.70		IMB1_HUMAN (539-1081): 9.24e-10: 65: 11.11
+	Hs
		179047 IMA6_HUMAN (4-514): 1.15e-139: 415: 44.07		IMB1_HUMAN (539-1081): 9.24e-10: 65: 11.11