HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: KDM6A (O15550)
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
Gene: KDM6A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.935

The method score is based on:

Property Details
Experiments 29785026, 24981860, 17761849, 32350066, 24491801, 17178841
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains JmjC~PHD
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0044666 - MLL3/4 complex
GO:0046872 - metal ion binding
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 5537
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024