Interactor 1: GNB5 (O14775)
Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)
Gene: GNB5

Interactor 2: RGS9 (O75916)
Regulator of G-protein signaling 9 (RGS9)
Gene: RGS9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 28514442, 33961781, 21511947
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DEP~WD40, G-gamma~WD40, RGS~WD40, RGS_DHEX~WD40
Common GO terms GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007212 - G protein-coupled dopamine receptor signaling pathway
and 2 others

more...

Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 395
Hs

1 674
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Bt
+ Hs
+ Hs
+ Ce
+ Hs
+ Ce
+ Ce
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024