HitPredict

Interactor 1: PTPRT (O14522)
Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)
Gene: PTPRT

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.53	1.00	0.733

Property	Details
Experiments	28065597
Identification Methods	two hybrid, affinity chromatography technology, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0009986 - cell surface GO:0016020 - membrane GO:0019903 - protein phosphatase binding and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1441 Hs			1 1210
+	Hs
		363315 PTPRK_HUMAN (23-1440): 0: 1125: 58.16		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		155415 PTPRT_HUMAN (26-1441): 0: 1182: 100.00		ERBB4_HUMAN (1-1208): 0: 1155: 49.12
+	Hs
		155408 PTPRT_HUMAN (26-1441): 0: 1182: 100.00		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		410858 PTPRK_HUMAN (23-1440): 0: 1125: 58.16		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		362742 PTPRA_HUMAN (723-1441): 0: 753: 32.56		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		362780 PTPRE_HUMAN (775-1441): 0: 735: 35.25		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		410603 PTPRA_HUMAN (723-1441): 0: 753: 32.56		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		363202 PTPRJ_HUMAN (206-1440): 2.64e-112: 388: 14.12		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		362779 PTPRD_HUMAN (17-927): 2.03e-74: 276: 13.24		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		410803 PTPRJ_HUMAN (206-1440): 2.64e-112: 388: 14.12		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		410876 PTPRO_HUMAN (1145-1435): 2.75e-97: 342: 27.27		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		439741 PTPRK_HUMAN (23-1440): 0: 1125: 58.16		INSR_HUMAN (336-637): 2.63e-27: 122: 21.64
+	Hs
		463898 PTPRA_HUMAN (723-1441): 0: 753: 32.56		RET_HUMAN (412-1058): 7.91e-132: 433: 23.02
+	Hs
		710272 PTPRO_HUMAN (1145-1435): 2.75e-97: 342: 27.27		EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79
+	Hs
		705683 PTPRM_HUMAN (15-1147): 4.95e-62: 236: 13.31		EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79
+	Hs
		1060771 PTPRJ_HUMAN (206-1440): 2.64e-112: 388: 14.12		ACK1_HUMAN (691-967): 4.56e-56: 214: 39.58
+	Hs
		849181 PTPRO_HUMAN (1145-1435): 2.75e-97: 342: 27.27		KSYK_HUMAN (716-961): 1.14e-53: 201: 41.70
+	Mm
		98155 PTPRO_MOUSE (1150-1435): 1.03e-95: 338: 28.87		FAK2_MOUSE (716-974): 4.24e-52: 201: 37.64
+	Hs
		439716 PTPRJ_HUMAN (206-1440): 2.64e-112: 388: 14.12		INSR_HUMAN (336-637): 2.63e-27: 122: 21.64
+	Hs
		439748 PTPRO_HUMAN (1145-1435): 2.75e-97: 342: 27.27		INSR_HUMAN (336-637): 2.63e-27: 122: 21.64