HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTPRD (P23468)
Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)
Gene: PTPRD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	24189400, unassigned2173
Identification Methods	affinity chromatography technology, ubiquitin reconstruction, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030182 - neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1912
+	Hs
		363225 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRS_HUMAN (1-1912): 0: 1575: 71.13
+	Hs
		362658 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRF_HUMAN (1-1912): 0: 1522: 68.73
+	Hs
		410550 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		PTPRF_HUMAN (1-1912): 0: 1522: 68.73
+	Hs
		362742 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRA_HUMAN (1176-1912): 0: 796: 42.05
+	Hs
		362780 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRE_HUMAN (1289-1912): 0: 774: 45.18
+	Hs
		362781 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRG_HUMAN (833-1909): 0: 727: 25.81
+	Hs
		410603 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		PTPRA_HUMAN (1176-1912): 0: 796: 42.05
+	Hs
		363202 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRJ_HUMAN (1615-1909): 2.89e-106: 374: 37.29
+	Hs
		362628 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRC_HUMAN (418-1627): 2.35e-84: 307: 14.95
+	Hs
		410537 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		PTPRC_HUMAN (418-1627): 2.35e-84: 307: 14.95
+	Hs
		363889 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRH_HUMAN (205-891): 7.73e-42: 170: 15.83
+	Hs
		362778 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRB_HUMAN (691-1428): 6.76e-23: 109: 12.17
+	Rn
		1224246 ERBB4_RAT (7-1208): 0: 1158: 49.04		PTPRZ_RAT (1329-1627): 5.97e-47: 188: 25.00
+	Hs
		155407 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRT_HUMAN (158-753): 5.54e-20: 99.7: 15.66
+	Hs
		363660 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRU_HUMAN (202-749): 2.52e-17: 91.2: 15.43
+	Hs
		363315 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PTPRK_HUMAN (95-729): 4.99e-16: 87: 14.99
+	Hs
		1145784 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		PTPRH_HUMAN (205-891): 7.73e-42: 170: 15.83
+	Hs
		155415 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		PTPRT_HUMAN (158-753): 5.54e-20: 99.7: 15.66
+	Hs
		410623 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		PTPRB_HUMAN (691-1428): 6.76e-23: 109: 12.17
+	Hs
		155408 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		PTPRT_HUMAN (158-753): 5.54e-20: 99.7: 15.66