HitPredict

Interactor 1: RPC1 (O14802)
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
Gene: POLR3A

Interactor 2: RPC9 (O75575)
DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)
Gene: CRCP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24981860, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RNA_pol_Rpb1_1~RNA_pol_Rpb4
Common GO terms	GO:0003899 - DNA-directed 5'-3' RNA polymerase activity GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex GO:0005829 - cytosol GO:0045087 - innate immune response and 1 others more... GO:0051607 - defense response to virus
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 148
+	Hs
		270181 RPB1_HUMAN (2-1382): 0: 1534: 32.10		RPC9_HUMAN (1-148): 1.67e-51: 162: 100.00
+	Sc
		375616 RPC1_YEAST (9-1383): 0: 1530: 49.93		RPC9_YEAST (1-121): 7.23e-30: 107: 28.93
+	Hs
		270169 RPA1_HUMAN (1147-1366): 4.77e-51: 200: 23.87		RPC9_HUMAN (1-148): 1.67e-51: 162: 100.00