HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.80	0.732

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, luminescence based mammalian interactome mapping, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SOCS_box, SH2~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 440
+	Hs
		557205 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SRC_HUMAN (134-389): 9.3e-44: 162: 12.50
+	Hs
		193250 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SOCS1_HUMAN (260-425): 3.01e-46: 160: 22.29
+	Mm
		813519 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		FYN_MOUSE (201-387): 5.13e-42: 157: 17.53
+	Hs
		155157 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SOCS7_HUMAN (209-439): 3.54e-40: 153: 22.76
+	Ce
		234031 SEM5_CAEEL (1-216): 5.16e-61: 192: 57.60		SRC2_CAEEL (165-414): 7.74e-42: 156: 16.09
+	Hs
		834167 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		CSK_HUMAN (245-379): 2.96e-33: 131: 19.12
+	Hs
		599281 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PLCG2_HUMAN (258-399): 9.79e-23: 103: 18.88
+	Mm
		1221223 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		PLCG1_MOUSE (271-379): 5.91e-22: 101: 18.18
+	Rn
		531972 GRB2_RAT (1-217): 1.28e-70: 216: 100.00		PLCG1_RAT (271-379): 3.92e-22: 101: 18.18
+	Hs
		619022 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PLCG1_HUMAN (271-379): 4.45e-22: 101: 18.18
+	Hs
		136362 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		P85B_HUMAN (241-382): 2.39e-18: 89.5: 20.69
+	Xl
		63585 GRB2A_XENLA (1-217): 3.3e-65: 202: 90.83		A5LHG3_XENLA (271-379): 3.79e-21: 98.8: 18.18
+	Hs
		987808 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		P55G_HUMAN (275-394): 7.76e-17: 84.1: 21.31
+	Mm
		686966 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		P85A_MOUSE (175-392): 1.74e-15: 80.6: 14.66
+	Hs
		699686 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		P85A_HUMAN (175-392): 1.31e-15: 81: 14.66
+	Rn
		1057713 LYN_RAT (3-202): 4.56e-34: 128: 27.01		SRC_RAT (133-389): 1.6e-44: 164: 12.45
+	Mm
		440286 LCK_MOUSE (3-202): 5.91e-38: 139: 28.44		SOCS6_MOUSE (220-424): 1.54e-40: 153: 29.68
+	Hs
		155063 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SOCS2_HUMAN (234-425): 1.65e-46: 160: 25.85
+	Mm
		440272 LCK_MOUSE (3-202): 5.91e-38: 139: 28.44		P85A_MOUSE (175-392): 1.74e-15: 80.6: 14.66
+	Hs
		136254 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		P85B_HUMAN (241-382): 2.39e-18: 89.5: 20.69