HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.619

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 1390
+	Hs
		471958 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		MET_HUMAN (1-1390): 0: 1275: 100.00
+	Hs
		222002 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		MET_HUMAN (1-1390): 0: 1275: 100.00
+	Hs
		439911 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		MET_HUMAN (1-1390): 0: 1275: 100.00
+	Hs
		462950 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		MET_HUMAN (1-1390): 0: 1275: 100.00
+	Hs
		156004 SOCS6_HUMAN (1-535): 0: 714: 100.00		FGFR3_HUMAN (982-1360): 1.05e-107: 362: 32.08
+	Hs
		155991 SOCS6_HUMAN (1-535): 0: 714: 100.00		INSR_HUMAN (1084-1335): 3.89e-55: 213: 42.11
+	Hs
		156042 SOCS6_HUMAN (1-535): 0: 714: 100.00		ERBB4_HUMAN (1082-1338): 4.99e-52: 203: 42.75
+	Hs
		222044 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		EPHA4_HUMAN (555-1389): 5.38e-174: 546: 17.20
+	Mm
		431334 SRC_MOUSE (236-495): 2.72e-52: 188: 15.19		EPHB2_MOUSE (597-1389): 1.81e-156: 500: 19.23
+	Hs
		462999 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		EPHB2_HUMAN (597-1389): 1.03e-155: 500: 19.23
+	Hs
		222024 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		UFO_HUMAN (1078-1333): 5.29e-66: 243: 45.90
+	Hs
		439967 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		UFO_HUMAN (1078-1333): 5.29e-66: 243: 45.90
+	Hs
		473422 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		ERBB4_HUMAN (1082-1338): 4.99e-52: 203: 42.75
+	Hs
		362129 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		222085 NCK2_HUMAN (182-466): 1.86e-57: 198: 17.04		ERBB4_HUMAN (1082-1338): 4.99e-52: 203: 42.75
+	Hs
		440083 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		ERBB4_HUMAN (1082-1338): 4.99e-52: 203: 42.75
+	Rn
		93228 D4A3M8_RAT (171-466): 1.35e-54: 190: 15.58		INSR_RAT (1084-1335): 3.23e-52: 204: 40.98
+	Mm
		431318 SRC_MOUSE (236-495): 2.72e-52: 188: 15.19		INSR_MOUSE (1084-1335): 2.22e-52: 204: 40.98
+	Hs
		439980 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		CSK_HUMAN (1082-1340): 5.48e-52: 192: 40.77
+	Hs
		834151 FRK_HUMAN (321-506): 2.07e-54: 193: 18.46		CSK_HUMAN (1082-1340): 5.48e-52: 192: 40.77