HitPredict

Interactor 1: CTRO (O14578)
Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21)
Gene: CIT

Interactor 2: ML12B (O14950)
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Gene: MYL12B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31586073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_7~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2027 Hs			1 172
+	Hs
		156970 CTRO_HUMAN (1-2027): 0: 1239: 100.00		MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02
+	Hs
		156943 CTRO_HUMAN (1-2027): 0: 1239: 100.00		ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37
+	Hs
		618698 MRCKA_HUMAN (26-941): 1.68e-134: 466: 25.40		ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37
+	Hs
		666780 AKT3_HUMAN (44-426): 4.88e-126: 407: 29.62		MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02
+	Rn
		616126 AAPK1_RAT (73-602): 1.48e-116: 383: 18.22		ML12B_RAT (1-172): 7.77e-67: 203: 99.42
+	Hs
		666750 AAPK1_HUMAN (73-610): 1.1e-116: 384: 18.13		MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02
+	At
		199575 CIPKD_ARATH (74-544): 1.23e-116: 381: 22.43		CDPKF_ARATH (1-166): 3.59e-54: 181: 22.94
+	Dm
		122288 M9PI41_DROME (554-1859): 2.16e-96: 349: 15.01		SQH_DROME (1-172): 1.45e-61: 189: 81.03
+	At
		1057378 KIN10_ARATH (96-455): 8.63e-121: 394: 23.08		CDPK1_ARATH (83-172): 4.09e-14: 71: 22.58
+	Rn
		516616 AAPK1_RAT (73-602): 1.48e-116: 383: 18.22		CALM1_RAT (20-93): 7.41e-10: 56.4: 24.36
+	Hs
		169045 MYH7_HUMAN (641-1590): 1.4e-45: 184: 10.50		ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00
+	At
		1043083 Q9LW66_ARATH (88-455): 9.29e-65: 233: 35.18		CALM6_ARATH (98-171): 6.78e-17: 74.9: 25.68
+	At
		515541 Q9LW66_ARATH (88-455): 9.29e-65: 233: 35.18		CALM4_ARATH (102-171): 9.94e-17: 74.5: 25.71
+	At
		947569 Q9LW66_ARATH (88-455): 9.29e-65: 233: 35.18		CALM7_ARATH (98-171): 2.62e-16: 73.3: 25.68
+	Dm
		614593 Q961D4_DROME (835-1537): 1.9e-47: 189: 13.41		MLR_DROME (13-163): 1.87e-29: 109: 42.21
+	At
		200298 Q9LW66_ARATH (88-455): 9.29e-65: 233: 35.18		CML8_ARATH (90-171): 5.14e-12: 62.1: 20.73
+	Mm
		906631 MYH6_MOUSE (392-979): 8.07e-27: 122: 11.79		MLRV_MOUSE (9-166): 3.71e-54: 170: 55.98
+	Hs
		270763 ROCK2_HUMAN (1041-1605): 5.82e-22: 106: 12.35		MLRV_HUMAN (9-166): 1.99e-54: 171: 57.23
+	Hs
		533985 MYH1_HUMAN (332-860): 4.45e-22: 106: 10.13		MLRV_HUMAN (9-166): 1.99e-54: 171: 57.23