HitPredict

Interactor 1: ML12B (O14950)
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Gene: MYL12B

Interactor 2: MYH7 (P12883)
Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)
Gene: MYH7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28524877
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head, EF-hand_7~Myosin_N, EF-hand_7~Myosin_tail_1
Common GO terms	GO:0001725 - stress fiber GO:0005737 - cytoplasm GO:0016460 - myosin II complex GO:0030016 - myofibril GO:0030018 - Z disc
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 172 Hs			1 1935
+	Hs
		533985 MLRV_HUMAN (9-166): 1.99e-54: 171: 57.23		MYH1_HUMAN (2-1935): 0: 1146: 81.00
+	Mm
		1223376 Q6ZWQ9_MOUSE (1-172): 7.04e-67: 203: 97.67		MYH10_MOUSE (26-1926): 0: 956: 40.75
+	Dm
		823778 SQH_DROME (1-172): 1.45e-61: 189: 81.03		MYSN_DROME (36-1926): 0: 969: 39.12
+	Hs
		169065 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH10_HUMAN (981-1935): 1.56e-62: 239: 18.48
+	Hs
		666741 MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02		MYH10_HUMAN (981-1935): 1.56e-62: 239: 18.48
+	Hs
		618654 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYH10_HUMAN (981-1935): 1.56e-62: 239: 18.48
+	Hs
		169066 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH11_HUMAN (720-1753): 3.59e-56: 218: 14.98
+	Hs
		169165 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH15_HUMAN (981-1935): 1.09e-54: 214: 18.24
+	Hs
		618655 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYH11_HUMAN (720-1753): 3.59e-56: 218: 14.98
+	Hs
		169064 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH9_HUMAN (1075-1934): 9.06e-49: 194: 15.81
+	Mm
		906631 MLRV_MOUSE (9-166): 3.71e-54: 170: 55.98		MYH6_MOUSE (722-1802): 1.06e-58: 227: 18.17
+	Hs
		666740 MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02		MYH9_HUMAN (1075-1934): 9.06e-49: 194: 15.81
+	Hs
		618653 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYH9_HUMAN (1075-1934): 9.06e-49: 194: 15.81
+	Ce
		386956 MLR1_CAEEL (24-170): 2.52e-39: 133: 49.32		MYO1_CAEEL (711-1560): 1.92e-40: 167: 13.15
+	Ce
		386957 MLR2_CAEEL (24-170): 1.92e-39: 133: 49.32		MYO1_CAEEL (711-1560): 1.92e-40: 167: 13.15
+	Hs
		692660 CALL3_HUMAN (32-93): 7.09e-11: 59: 25.76		MYH9_HUMAN (1075-1934): 9.06e-49: 194: 15.81
+	Dm
		432167 MLR_DROME (13-163): 1.87e-29: 109: 42.21		MYSA_DROME (722-1250): 2.55e-22: 107: 14.37
+	Ce
		386945 MLR1_CAEEL (24-170): 2.52e-39: 133: 49.32		MYO4_CAEEL (733-1146): 1.58e-12: 75.5: 12.80
+	Ce
		386946 MLR2_CAEEL (24-170): 1.92e-39: 133: 49.32		MYO4_CAEEL (733-1146): 1.58e-12: 75.5: 12.80