HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9614078
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 303
+	Hs
		160439 IRS4_HUMAN (1-1257): 0: 1632: 100.00		CRK_HUMAN (3-302): 1.42e-51: 173: 54.89
+	Hs
		160410 IRS4_HUMAN (1-1257): 0: 1632: 100.00		PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60
+	Hs
		160469 IRS4_HUMAN (1-1257): 0: 1632: 100.00		GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89
+	Dm
		1061488 IRS1_DROME (83-354): 1.31e-71: 261: 30.00		GRAP_DROME (126-293): 1.92e-22: 94.5: 17.31
+	Mm
		772560 IRS1_MOUSE (685-1099): 2.44e-15: 83.7: 18.51		CRK_MOUSE (3-302): 9.88e-52: 174: 54.89
+	Hs
		619141 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60
+	Mm
		1010411 IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68		GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89
+	Rn
		98918 F1MAL5_RAT (601-1085): 2.46e-23: 109: 22.37		GRB2_RAT (126-295): 3.56e-23: 96.8: 15.89
+	Hs
		599274 IRS1_HUMAN (685-1104): 4.2e-16: 86.4: 19.17		PLCG2_HUMAN (5-192): 1.58e-26: 111: 18.23
+	Hs
		988063 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89
+	Hs
		772479 IRS1_HUMAN (685-1104): 4.2e-16: 86.4: 19.17		GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89
+	Mm
		772556 IRS1_MOUSE (685-1099): 2.44e-15: 83.7: 18.51		GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89
+	Rn
		772588 IRS1_RAT (685-1099): 3.07e-15: 83.3: 19.47		GRB2_RAT (126-295): 3.56e-23: 96.8: 15.89
+	Hs
		222025 IRS1_HUMAN (685-1104): 4.2e-16: 86.4: 19.17		NCK2_HUMAN (13-98): 9.64e-18: 84.4: 29.89
+	Hs
		772533 IRS1_HUMAN (685-1104): 4.2e-16: 86.4: 19.17		CD2AP_HUMAN (242-303): 1.75e-12: 69.7: 28.57