HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: WDR74 (Q6RFH5)
WD repeat-containing protein 74 (NOP seven-associated protein 1)
Gene: WDR74

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 385
+	Hs
		161486 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		WDR5B_HUMAN (162-383): 5.59e-52: 178: 11.66
+	Hs
		161502 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		FBXW7_HUMAN (3-154): 1.36e-20: 95.6: 15.39
+	Hs
		161490 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		POC1A_HUMAN (257-383): 6.59e-20: 92.2: 11.02
+	Hs
		161443 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		WDR5_HUMAN (3-113): 5.77e-14: 74.1: 5.98
+	Hs
		1155922 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		FBW1A_HUMAN (24-374): 1.55e-71: 236: 14.72
+	Hs
		1155888 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		FBW1B_HUMAN (38-374): 1.3e-67: 224: 13.58
+	Hs
		216486 SUV91_HUMAN (5165-5536): 1.72e-93: 313: 18.38		DAW1_HUMAN (100-384): 5.95e-59: 198: 10.88
+	Hs
		1155740 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		SKI8_HUMAN (94-299): 5.27e-59: 195: 21.26
+	Sc
		863930 SET2_YEAST (5266-5536): 1.28e-76: 274: 21.32		NSA1_YEAST (96-353): 1.24e-71: 233: 25.25
+	Hs
		1380086 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		FBXW7_HUMAN (3-154): 1.36e-20: 95.6: 15.39
+	Hs
		965167 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		WDR5_HUMAN (3-113): 5.77e-14: 74.1: 5.98
+	Dm
		1208005 SET1_DROME (5244-5537): 1.14e-75: 284: 28.49		WDS_DROME (1-258): 2.5e-51: 177: 10.65
+	Hs
		1155633 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		FBXW7_HUMAN (3-154): 1.36e-20: 95.6: 15.39
+	At
		1421791 ATX1_ARATH (5318-5537): 4.12e-68: 255: 33.20		WDR5A_ARATH (222-384): 1.41e-41: 150: 10.71
+	Hs
		284952 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		TAF5L_HUMAN (100-321): 9.66e-18: 86.8: 16.40
+	Hs
		1041594 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		SKI8_HUMAN (94-299): 5.27e-59: 195: 21.26
+	Hs
		1041578 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		SNR40_HUMAN (2-253): 7.03e-50: 173: 12.06
+	Hs
		1041577 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		FBXW7_HUMAN (3-154): 1.36e-20: 95.6: 15.39
+	Hs
		964869 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		WDR5_HUMAN (3-113): 5.77e-14: 74.1: 5.98
+	Hs
		965330 KMT2B_HUMAN (79-219): 7.15e-25: 118: 24.31		WDR5_HUMAN (3-113): 5.77e-14: 74.1: 5.98