HitPredict

Interactor 1: SC16A (O15027)
Protein transport protein Sec16A (SEC16 homolog A) (p250)
Gene: SEC16A

Interactor 2: SEC13 (P55735)
Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)
Gene: SEC13

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	28514442, 33961781, 35271311, 26496610, 25201882
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Sec16_C~WD40
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0012507 - ER to Golgi transport vesicle membrane GO:0032527 - protein exit from endoplasmic reticulum
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2357 Hs			1 322
+	Hs
		164994 SC16A_HUMAN (1-2357): 0: 820: 100.00		FBXW7_HUMAN (87-316): 1.49e-41: 154: 14.72
+	Hs
		164723 SC16A_HUMAN (1-2357): 0: 820: 100.00		CIAO1_HUMAN (12-93): 1.73e-09: 60: 28.09
+	Hs
		878230 SC16B_HUMAN (1211-2253): 2.32e-80: 291: 29.25		SEC13_HUMAN (1-322): 1.89e-85: 261: 100.00
+	Hs
		92559 E9PK14_HUMAN (1187-1787): 3.42e-75: 266: 34.49		SEC13_HUMAN (1-322): 1.89e-85: 261: 100.00
+	Hs
		302272 SC31A_HUMAN (26-347): 7.63e-09: 63.5: 12.31		SEC13_HUMAN (1-322): 1.89e-85: 261: 100.00
+	Hs
		867085 SC24C_HUMAN (716-1040): 9.25e-09: 63.3: 17.02		SEC13_HUMAN (1-322): 1.89e-85: 261: 100.00
+	Ce
		109930 H2KZQ8_CAEEL (715-2205): 2.57e-50: 199: 13.61		SEC13_CAEEL (100-321): 1.03e-31: 122: 21.40
+	Dm
		52415 A1Z7J7_DROME (867-1199): 4.5e-09: 64.3: 13.70		SEC13_DROME (1-305): 1.44e-72: 230: 57.33
+	Ce
		712434 SC161_CAEEL (1432-2256): 2.55e-38: 160: 20.26		SEC13_CAEEL (100-321): 1.03e-31: 122: 21.40
+	Hs
		1057782 NCOA6_HUMAN (24-1116): 2.4e-18: 95.1: 8.40		FBXW7_HUMAN (87-316): 1.49e-41: 154: 14.72
+	Sc
		817597 SEC16_YEAST (835-2347): 2.61e-42: 174: 13.25		SEC13_YEAST (4-89): 5.8e-10: 61.3: 25.00
+	Hs
		1281391 PRR36_HUMAN (1219-2346): 2.98e-11: 71.6: 10.73		FBXW7_HUMAN (87-316): 1.49e-41: 154: 14.72
+	Hs
		1302927 MINT_HUMAN (3-1242): 2.25e-12: 75.2: 13.32		NLE1_HUMAN (196-317): 5.64e-28: 114: 20.49
+	Hs
		1288258 MINT_HUMAN (3-1242): 2.25e-12: 75.2: 13.32		SNR40_HUMAN (3-131): 4.97e-25: 104: 22.22
+	Hs
		903229 NCOA6_HUMAN (24-1116): 2.4e-18: 95.1: 8.40		WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67
+	Sp
		142026 SEC31_SCHPO (11-377): 9.75e-09: 63.1: 10.51		SEC13_SCHPO (3-147): 3.98e-14: 73.2: 24.85
+	Mm
		903669 KMT2C_MOUSE (1864-2326): 2.89e-11: 71.9: 12.13		WDR5_MOUSE (249-320): 1.4e-10: 63.3: 16.67
+	Hs
		903374 KMT2C_HUMAN (1891-2314): 1.21e-10: 69.8: 14.58		WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67
+	Hs
		302275 SC31A_HUMAN (26-347): 7.63e-09: 63.5: 12.31		WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67
+	Sc
		758551 SEC31_YEAST (5-336): 7.22e-09: 63.4: 12.47		SEC13_YEAST (4-89): 5.8e-10: 61.3: 25.00