Protein: SH21A
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)

Gene: SH21A, SH2D1A
Organism: Homo sapiens
Interactions: 53
UniProt ID: O60880

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006959 - humoral immune response
GO:0006968 - cellular defense response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

258579

FYN
Tyrosine-protein kinase Fyn

4

18

Small-scale

0.894

High

258594

ACK1
Activated CDC42 kinase 1

2

19

High-throughput

0.845

High

258599

ARHG7
Rho guanine nucleotide exchange factor 7

2

20

Small-scale

0.781

High

258574

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.778

High

258585

NCK1
SH2/SH3 adapter protein NCK1

2

19

High-throughput

0.767

High

258593

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.767

High

258595

SLAF1
Signaling lymphocytic activation molecule

15

20

Small-scale

0.762

High

258613

CD244
Natural killer cell receptor 2B4

12

20

Small-scale

0.756

High

258606

NGEF
Ephexin-1

2

20

High-throughput

0.743

High

258619

SLAF5
SLAM family member 5

7

20

Small-scale

0.738

High

258611

SLAF6
SLAM family member 6

6

20

Small-scale

0.728

High

258578

LCK
Tyrosine-protein kinase Lck

2

18

Small-scale

0.726

High

178063

FYB1
FYN-binding protein 1

1

17

Small-scale

0.713

High

258589

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.696

High

258600

ARHG6
Rho guanine nucleotide exchange factor 6

1

20

Small-scale

0.683

High

258584

SRC
Proto-oncogene tyrosine-protein kinase Src

1

18

High-throughput

0.665

High

258576

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

258601

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

258615

LY9
T-lymphocyte surface antigen Ly-9

4

20

Small-scale

0.632

High

258581

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

258583

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.619

High

258580

LYN
Tyrosine-protein kinase Lyn

1

18

Small-scale

0.618

High

258608

LHX4
LIM/homeobox protein Lhx4

2

7

High-throughput

0.600

High

258616

SLAF7
SLAM family member 7

2

20

Small-scale

0.595

High

258612

DOK1
Docking protein 1

1

20

Small-scale

0.586

High

164836

SH21B
SH2 domain-containing protein 1B

1

18

Small-scale

0.575

High

258588

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

6

Small-scale

0.554

High

258618

LHX3
LIM/homeobox protein Lhx3

2

7

High-throughput

0.553

High

258586

ATF3
Cyclic AMP-dependent transcription factor ATF-3

2

8

High-throughput

0.542

High

258582

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

258604

LTMD1
LETM1 domain-containing protein 1

2

1

High-throughput

0.526

High

258607

OLIG1
Oligodendrocyte transcription factor 1

2

4

High-throughput

0.526

High

258587

CD22
B-cell receptor CD22

1

20

Small-scale

0.515

High

258614

NIF3L
NIF3-like protein 1

1

2

High-throughput

0.515

High

258575

FOS
Protein c-Fos

1

6

High-throughput

0.515

High

258610

DDT4L
DNA damage-inducible transcript 4-like protein

1

4

High-throughput

0.515

High

258602

MK11
Mitogen-activated protein kinase 11

1

9

Small-scale

0.501

High

258603

MK14
Mitogen-activated protein kinase 14

1

9

Small-scale

0.501

High

258592

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.500

High

258621

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

20

High-throughput

0.489

High

224533

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.479

High

258591

TERA
Transitional endoplasmic reticulum ATPase

1

4

Small-scale

0.479

High

258596

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

15

High-throughput

0.479

High

258597

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

14

High-throughput

0.479

High

258598

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

12

High-throughput

0.479

High

188586

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.437

High

258577

CD5
T-cell surface glycoprotein CD5

1

4

Small-scale

0.437

High

258590

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

20

Small-scale

0.437

High

258617

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

8

Small-scale

0.437

High

258620

SIGL7
Sialic acid-binding Ig-like lectin 7

1

20

Small-scale

0.437

High

211612

ZNHI1
Zinc finger HIT domain-containing protein 1

2

0

High-throughput

0.310

High

258609

CC74A
Coiled-coil domain-containing protein 74A

2

0

High-throughput

0.300

High

258605

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025