HitPredict

Interactor 1: MUSK (O15146)
Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)
Gene: MUSK

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 869 Hs			1 248
+	Hs
		169169 MUSK_HUMAN (1-869): 0: 794: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		909494 MERTK_HUMAN (111-865): 1.2e-148: 465: 22.37		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		674386 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646846 MERTK_HUMAN (111-865): 1.2e-148: 465: 22.37		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		674348 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		683304 MERTK_HUMAN (111-865): 1.2e-148: 465: 22.37		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		411316 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		435554 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		435597 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		601493 FGFR2_HUMAN (21-330): 7.1e-72: 255: 20.05		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		435604 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		435542 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		601470 FGFR2_HUMAN (21-330): 7.1e-72: 255: 20.05		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		411315 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		435553 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		435594 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		507877 FGFR1_HUMAN (1-330): 4.65e-67: 241: 17.79		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Dm
		448232 INSR_DROME (539-864): 7.85e-66: 243: 38.34		1433Z_DROME (1-245): 4.71e-99: 290: 66.12
+	Hs
		607896 FGFR4_HUMAN (10-301): 5.06e-66: 238: 18.26		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		646811 ROR2_HUMAN (30-121): 4.69e-20: 97.8: 27.66		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85