HitPredict

Interactor 1: MYL9 (P24844)
Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1)
Gene: MYL9

Interactor 2: MYH10 (P35580)
Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)
Gene: MYH10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 31839598
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~IQ, EF-hand_7~Myosin_head, EF-hand_7~Myosin_N, EF-hand_7~Myosin_tail_1
Common GO terms	GO:0001725 - stress fiber GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005938 - cell cortex GO:0016460 - myosin II complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 172 Hs			1 1976
+	Ce
		110227 CALM_CAEEL (97-171): 2.63e-15: 70.7: 25.33		G5EBY3_CAEEL (23-1927): 0: 1312: 45.99
+	Mm
		1223376 Q6ZWQ9_MOUSE (1-172): 1.03e-66: 202: 93.61		MYH10_MOUSE (1-1976): 0: 1093: 99.09
+	Hs
		169065 ML12B_HUMAN (1-172): 9.17e-67: 203: 93.02		MYH10_HUMAN (1-1976): 0: 1086: 100.00
+	Hs
		618654 ML12A_HUMAN (15-172): 7.79e-65: 198: 94.30		MYH10_HUMAN (1-1976): 0: 1086: 100.00
+	Hs
		169064 ML12B_HUMAN (1-172): 9.17e-67: 203: 93.02		MYH9_HUMAN (8-1930): 0: 1056: 78.89
+	Hs
		666740 MYL9_HUMAN (1-172): 1.53e-66: 202: 100.00		MYH9_HUMAN (8-1930): 0: 1056: 78.89
+	Hs
		618653 ML12A_HUMAN (15-172): 7.79e-65: 198: 94.30		MYH9_HUMAN (8-1930): 0: 1056: 78.89
+	Hs
		169114 ML12B_HUMAN (1-172): 9.17e-67: 203: 93.02		MYH14_HUMAN (27-1930): 0: 1013: 68.33
+	Hs
		618709 ML12A_HUMAN (15-172): 7.79e-65: 198: 94.30		MYH14_HUMAN (27-1930): 0: 1013: 68.33
+	Mm
		906631 MLRV_MOUSE (9-166): 2.18e-53: 168: 55.98		MYH6_MOUSE (986-1976): 7.19e-58: 224: 17.98
+	Hs
		169045 ML12B_HUMAN (1-172): 9.17e-67: 203: 93.02		MYH7_HUMAN (723-1572): 2.21e-46: 186: 16.34
+	Hs
		169066 ML12B_HUMAN (1-172): 9.17e-67: 203: 93.02		MYH11_HUMAN (734-1645): 2.37e-45: 183: 16.61
+	Hs
		618655 ML12A_HUMAN (15-172): 7.79e-65: 198: 94.30		MYH11_HUMAN (734-1645): 2.37e-45: 183: 16.61
+	Hs
		533985 MLRV_HUMAN (9-166): 3.22e-54: 171: 57.23		MYH1_HUMAN (1129-1976): 1.62e-48: 193: 17.35
+	Dm
		432167 MLR_DROME (3-163): 7.61e-30: 110: 40.61		MYSA_DROME (979-1976): 1.38e-61: 236: 18.20
+	Ce
		386945 MLR1_CAEEL (24-170): 1.34e-38: 131: 48.65		MYO4_CAEEL (732-1537): 4.25e-40: 165: 17.70
+	Ce
		386946 MLR2_CAEEL (24-170): 1.02e-38: 131: 48.65		MYO4_CAEEL (732-1537): 4.25e-40: 165: 17.70
+	Dm
		823778 SQH_DROME (1-172): 4.43e-61: 188: 80.46		MYSN_DROME (734-1130): 6.37e-11: 70.1: 15.10
+	Ce
		386956 MLR1_CAEEL (24-170): 1.34e-38: 131: 48.65		MYO1_CAEEL (734-1352): 7.74e-21: 102: 13.39
+	Ce
		386957 MLR2_CAEEL (24-170): 1.02e-38: 131: 48.65		MYO1_CAEEL (734-1352): 7.74e-21: 102: 13.39