HitPredict

Interactor 1: ML12A (P19105)
Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)
Gene: MYL12A

Interactor 2: MYH11 (P35749)
Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)
Gene: MYH11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head, EF-hand_7~Myosin_N, EF-hand_7~Myosin_tail_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016460 - myosin II complex GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 171 Hs			1 1972
+	Hs
		169066 ML12B_HUMAN (13-171): 2.04e-65: 199: 99.37		MYH11_HUMAN (1-1972): 0: 1116: 100.00
+	Hs
		618653 ML12A_HUMAN (1-171): 7.98e-66: 200: 100.00		MYH9_HUMAN (893-1971): 1.08e-64: 246: 19.19
+	Hs
		169064 ML12B_HUMAN (13-171): 2.04e-65: 199: 99.37		MYH9_HUMAN (893-1971): 1.08e-64: 246: 19.19
+	Hs
		666740 MYL9_HUMAN (14-171): 9.66e-65: 197: 94.30		MYH9_HUMAN (893-1971): 1.08e-64: 246: 19.19
+	Hs
		618654 ML12A_HUMAN (1-171): 7.98e-66: 200: 100.00		MYH10_HUMAN (969-1972): 2.01e-58: 226: 17.23
+	Hs
		169065 ML12B_HUMAN (13-171): 2.04e-65: 199: 99.37		MYH10_HUMAN (969-1972): 2.01e-58: 226: 17.23
+	Hs
		666741 MYL9_HUMAN (14-171): 9.66e-65: 197: 94.30		MYH10_HUMAN (969-1972): 2.01e-58: 226: 17.23
+	Dm
		823778 SQH_DROME (1-171): 6.77e-61: 188: 80.46		MYSN_DROME (986-1972): 2.4e-61: 235: 18.91
+	Mm
		1223376 Q6ZWQ9_MOUSE (1-171): 1.8e-64: 196: 97.09		MYH10_MOUSE (1088-1972): 1.56e-55: 216: 16.91
+	Hs
		618709 ML12A_HUMAN (1-171): 7.98e-66: 200: 100.00		MYH14_HUMAN (973-1971): 6.21e-51: 201: 17.17
+	Hs
		169114 ML12B_HUMAN (13-171): 2.04e-65: 199: 99.37		MYH14_HUMAN (973-1971): 6.21e-51: 201: 17.17
+	Mm
		906631 MLRV_MOUSE (9-165): 6.17e-55: 172: 56.96		MYH6_MOUSE (1016-1972): 2.67e-58: 225: 17.06
+	Hs
		169045 ML12B_HUMAN (13-171): 2.04e-65: 199: 99.37		MYH7_HUMAN (736-1650): 3e-48: 192: 17.13
+	Dm
		432167 MLR_DROME (8-162): 4.12e-30: 110: 41.14		MYSA_DROME (874-1972): 1.5e-68: 259: 17.94
+	Ce
		386956 MLR1_CAEEL (23-169): 2.26e-39: 133: 49.32		MYO1_CAEEL (1012-1970): 2.5e-55: 216: 15.39
+	Ce
		386957 MLR2_CAEEL (23-169): 1.94e-39: 133: 49.32		MYO1_CAEEL (1012-1970): 2.5e-55: 216: 15.39
+	Ce
		386945 MLR1_CAEEL (23-169): 2.26e-39: 133: 49.32		MYO4_CAEEL (734-1706): 1.01e-51: 204: 15.00
+	Ce
		386946 MLR2_CAEEL (23-169): 1.94e-39: 133: 49.32		MYO4_CAEEL (734-1706): 1.01e-51: 204: 15.00
+	Hs
		533985 MLRV_HUMAN (9-165): 3e-55: 173: 58.23		MYH1_HUMAN (1463-1972): 5.79e-30: 132: 17.65
+	Hs
		692660 CALL3_HUMAN (31-92): 8.66e-11: 58.6: 27.27		MYH9_HUMAN (893-1971): 1.08e-64: 246: 19.19