HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: K1H1 (Q15323)
Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1) (Keratin-31) (K31)
Gene: KRT31

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	25416956, 32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 416
+	Hs
		169361 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		KRT37_HUMAN (17-409): 1.92e-148: 430: 60.91
+	Hs
		169593 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K1C40_HUMAN (6-385): 2.33e-143: 416: 62.69
+	Hs
		169381 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K1C14_HUMAN (54-367): 6.74e-142: 414: 61.15
+	Hs
		169401 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K1C19_HUMAN (48-366): 8.95e-141: 409: 56.11
+	Hs
		169594 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K1C39_HUMAN (36-416): 1.52e-133: 394: 62.30
+	Hs
		169402 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K1C16_HUMAN (54-382): 2.64e-115: 347: 58.36
+	Hs
		169431 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K1C15_HUMAN (55-367): 1.79e-111: 336: 57.96
+	Hs
		169416 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K1C13_HUMAN (50-373): 2.1e-108: 328: 56.00
+	Hs
		169342 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		KRT86_HUMAN (4-413): 4.92e-100: 308: 24.64
+	Hs
		169371 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K2C75_HUMAN (19-381): 5.07e-95: 297: 26.58
+	Hs
		169359 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		KRT34_HUMAN (1-391): 2.98e-95: 292: 89.00
+	Hs
		169767 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		KRT82_HUMAN (4-413): 2.29e-93: 292: 24.33
+	Hs
		169362 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		KRT38_HUMAN (11-413): 1.22e-92: 288: 60.89
+	Hs
		169680 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		KRT35_HUMAN (2-412): 4.84e-87: 273: 69.83
+	Hs
		169382 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		K2C6A_HUMAN (19-391): 4.52e-83: 266: 24.27
+	Hs
		169360 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		KRT36_HUMAN (4-400): 1.13e-81: 260: 69.65
+	Hs
		169553 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		KT33B_HUMAN (1-414): 1.1e-82: 260: 91.55
+	Hs
		3373 A0A0S2Z4Q4_HUMAN (1-688): 1.44e-48: 185: 41.85		K1C13_HUMAN (50-373): 2.1e-108: 328: 56.00
+	Hs
		3371 A0A0S2Z4Q4_HUMAN (1-688): 1.44e-48: 185: 41.85		KRT38_HUMAN (11-413): 1.22e-92: 288: 60.89