Protein: PHS
Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)

Gene: PHS, PCBD1
Organism: Homo sapiens
Interactions: 112
UniProt ID: P61457

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0004505 - phenylalanine 4-monooxygenase activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006729 - tetrahydrobiopterin biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900025

PHS
Pterin-4-alpha-carbinolamine dehydratase

7

5

Small-scale

0.968

High

900071

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

2

5

High-throughput

0.817

High

727496

HNF1B
Hepatocyte nuclear factor 1-beta

6

6

High-throughput

0.737

High

843997

FXR2
RNA-binding protein FXR2

5

0

High-throughput

0.687

High

595917

HNF1A
Hepatocyte nuclear factor 1-alpha

5

6

Small-scale

0.659

High

900062

NTAQ1
Protein N-terminal glutamine amidohydrolase

3

0

High-throughput

0.639

High

132807

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

637378

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.580

High

900079

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

394460

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.578

High

900085

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.578

High

900040

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

1

High-throughput

0.553

High

900091

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

1

Small-scale

0.552

High

156010

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

1

High-throughput

0.541

High

587494

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

High-throughput

0.541

High

622104

ZBT25
Zinc finger and BTB domain-containing protein 25

1

1

High-throughput

0.541

High

900075

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

1

High-throughput

0.541

High

900078

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.541

High

900026

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.537

High

474980

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.536

High

900033

CUL1
Cullin-1

1

4

High-throughput

0.536

High

900034

CUL3
Cullin-3

1

4

High-throughput

0.536

High

900035

CUL4A
Cullin-4A

1

4

High-throughput

0.536

High

900036

CUL4B
Cullin-4B

1

4

High-throughput

0.536

High

900041

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.536

High

900047

PHF6
PHD finger protein 6

1

1

High-throughput

0.536

High

900048

ZZZ3
ZZ-type zinc finger-containing protein 3

1

1

High-throughput

0.536

High

900055

CUL5
Cullin-5

1

4

High-throughput

0.536

High

123896

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.518

High

150933

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.518

High

265182

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.518

High

782511

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

High-throughput

0.518

High

900029

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

High-throughput

0.518

High

900031

RBL2
Retinoblastoma-like protein 2

1

0

High-throughput

0.518

High

900042

M18BP
Mis18-binding protein 1

1

0

High-throughput

0.518

High

900045

NUD18
8-oxo-dGDP phosphatase NUDT18

1

0

High-throughput

0.518

High

900046

MYCPP
C-myc promoter-binding protein

1

0

High-throughput

0.518

High

900058

SCMH1
Polycomb protein SCMH1

1

0

High-throughput

0.518

High

900060

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.518

High

900067

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.518

High

900068

TRIM5
Tripartite motif-containing protein 5

1

0

High-throughput

0.518

High

900070

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

0

High-throughput

0.518

High

900082

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

0

High-throughput

0.518

High

900088

TIM
Protein timeless homolog

1

0

High-throughput

0.518

High

900094

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.518

High

56520

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

0

High-throughput

0.513

High

266333

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.513

High

900028

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.513

High

900050

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.513

High

900054

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

900059

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

900073

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

900077

GPCP1
Glycerophosphocholine phosphodiesterase GPCPD1

1

0

High-throughput

0.513

High

900080

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.513

High

900087

YETS2
YEATS domain-containing protein 2

1

0

High-throughput

0.513

High

150362

ZN195
Zinc finger protein 195

1

1

High-throughput

0.494

High

161807

ZN263
Zinc finger protein 263

1

3

High-throughput

0.494

High

304689

ZN202
Zinc finger protein 202

1

1

High-throughput

0.494

High

900064

ZN714
Zinc finger protein 714

1

1

High-throughput

0.494

High

900076

HES4
Transcription factor HES-4

1

1

High-throughput

0.494

High

900090

KLF13
Krueppel-like factor 13

1

1

High-throughput

0.494

High

639713

IKBA
NF-kappa-B inhibitor alpha

1

1

High-throughput

0.479

High

702874

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.479

High

839929

F10A1
Hsc70-interacting protein

1

1

High-throughput

0.479

High

846734

SMCA2
Probable global transcription activator SNF2L2

1

1

High-throughput

0.479

High

900032

KIF5A
Kinesin heavy chain isoform 5A

1

1

High-throughput

0.479

High

336283

PH4H
Phenylalanine-4-hydroxylase

1

0

Small-scale

0.460

High

900065

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

High-throughput

0.460

High

208827

CHM2A
Charged multivesicular body protein 2a

1

0

High-throughput

0.458

High

373985

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

503810

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

505607

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

582172

NUCL
Nucleolin

1

0

High-throughput

0.458

High

631129

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

807669

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

900027

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.458

High

900038

MAP7
Ensconsin

1

0

High-throughput

0.458

High

900043

CPLX2
Complexin-2

1

0

High-throughput

0.458

High

900044

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

900057

THOC1
THO complex subunit 1

1

0

High-throughput

0.458

High

900084

SAE2
SUMO-activating enzyme subunit 2

1

0

High-throughput

0.458

High

900093

PRC2C
Protein PRRC2C

1

0

High-throughput

0.458

High

306059

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

900072

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

473653

ZN688
Zinc finger protein 688

1

2

High-throughput

0.439

High

900053

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

378014

PRIO
Major prion protein

1

0

High-throughput

0.426

High

3393

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

1

High-throughput

0.417

High

900074

GORS2
Golgi reassembly-stacking protein 2

5

0

High-throughput

0.374

High

900051

LNX1
E3 ubiquitin-protein ligase LNX

4

0

High-throughput

0.368

High

900030

TFF3
Trefoil factor 3

3

0

High-throughput

0.352

High

563531

ZNF23
Zinc finger protein 23

1

0

High-throughput

0.282

High

900039

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

0

High-throughput

0.282

High

900049

ZN567
Zinc finger protein 567

1

0

High-throughput

0.282

High

900069

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.282

High

900089

DIP2C
Disco-interacting protein 2 homolog C

1

0

High-throughput

0.282

High

900092

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.282

High

321986

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

900052

DNJB3
DnaJ homolog subfamily B member 3

1

0

High-throughput

0.279

Low

900056

C102A
Coiled-coil domain-containing protein 102A

1

0

High-throughput

0.279

Low

900037

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

Small-scale

0.251

Low

100647

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

530863

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.249

Low

599559

SYT1
Synaptotagmin-1

1

0

High-throughput

0.249

Low

602961

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.249

Low

900061

PGCB
Brevican core protein

1

0

High-throughput

0.249

Low

900063

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.249

Low

900066

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

900081

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

0

High-throughput

0.249

Low

900083

F135A
Protein FAM135A

1

0

High-throughput

0.249

Low

900086

MYT1L
Myelin transcription factor 1-like protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024