HitPredict

Interactor 1: SPTC1 (O15269)
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)
Gene: SPTLC1

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 473 Hs			1 465
+	Hs
		174181 SPTC2_HUMAN (18-473): 8.05e-154: 450: 24.74		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226066 KBL_HUMAN (83-470): 3.45e-114: 344: 26.34		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226391 HEM1_HUMAN (50-473): 3.76e-109: 338: 22.15		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		270906 KBL_HUMAN (83-470): 3.45e-114: 344: 26.34		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091933 GLYP3_ARATH (45-466): 1.38e-83: 268: 15.10		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1092415 GLYM1_ARATH (59-469): 3.08e-81: 262: 13.11		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		791089 GSA1_ARATH (48-471): 9.91e-82: 262: 14.17		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091677 GSA2_ARATH (48-471): 1.44e-80: 259: 14.38		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17