HitPredict

Interactor 1: BIRC5 (O15392)
Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Gene: BIRC5

Interactor 2: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	9850056, 11170436
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 142 Hs			1 303
+	Hs
		876964 BIRC6_HUMAN (8-88): 8.14e-36: 132: 37.04		CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00
+	Hs
		876960 BIRC7_HUMAN (7-104): 1.33e-33: 121: 29.59		CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00
+	Hs
		876944 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00
+	Hs
		177658 BIRC5_HUMAN (1-142): 2.27e-60: 184: 100.00		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		788230 BIRC6_HUMAN (8-88): 8.14e-36: 132: 37.04		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		177664 BIRC5_HUMAN (1-142): 2.27e-60: 184: 100.00		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Hs
		788221 BIRC7_HUMAN (7-104): 1.33e-33: 121: 29.59		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		788193 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		1059377 BIRC6_HUMAN (8-88): 8.14e-36: 132: 37.04		CASP8_HUMAN (9-301): 8.96e-93: 284: 34.42
+	Hs
		877004 BIRC6_HUMAN (8-88): 8.14e-36: 132: 37.04		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Dm
		136289 DIAP1_DROME (8-89): 7.6e-22: 91.3: 26.83		DRICE_DROME (33-302): 2.73e-108: 319: 43.02
+	Hs
		876987 Q6PIA0_HUMAN (12-122): 1.73e-36: 126: 26.13		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Hs
		876998 BIRC8_HUMAN (12-122): 3.28e-36: 126: 26.13		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Dm
		137119 DIAP1_DROME (8-89): 7.6e-22: 91.3: 26.83		CASP1_DROME (20-302): 1.17e-105: 312: 39.72
+	Hs
		876997 BIRC7_HUMAN (7-104): 1.33e-33: 121: 29.59		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Hs
		1035745 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP8_HUMAN (9-301): 8.96e-93: 284: 34.42
+	Hs
		876980 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Hs
		1035946 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASPA_HUMAN (33-251): 4.8e-81: 256: 36.32
+	Hs
		667461 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CASP1_HUMAN (1-301): 8.45e-79: 246: 21.04
+	Hs
		181612 BIRC3_HUMAN (3-96): 8.83e-22: 91.7: 27.66		CFLAR_HUMAN (55-302): 9.84e-60: 199: 23.08