HitPredict

Interactor 1: YKT6 (O15498)
Synaptobrevin homolog YKT6 (EC 2.3.1.-)
Gene: YKT6

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005768 - endosome GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 236
+	Hs
		180766 YKT6_HUMAN (1-198): 2.95e-72: 218: 100.00		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Hs
		235130 SC22B_HUMAN (1-196): 2.72e-63: 196: 19.60		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	Dm
		1374685 Q9W3M8_DROME (1-196): 9.21e-71: 215: 61.74		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		263392 SC22B_HUMAN (1-196): 2.72e-63: 196: 19.60		STX8_HUMAN (1-218): 7.54e-47: 156: 100.00
+	At
		812701 VA722_ARATH (22-194): 8.26e-69: 210: 20.43		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	At
		1351793 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	Hs
		212690 SC22B_HUMAN (1-196): 2.72e-63: 196: 19.60		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Dm
		115843 M9PGI6_DROME (3-195): 3.74e-59: 185: 21.03		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		180779 YKT6_HUMAN (1-198): 2.95e-72: 218: 100.00		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Sc
		731077 YKT6_YEAST (1-198): 9.98e-69: 209: 47.00		TLG1_YEAST (2-220): 3.95e-32: 118: 15.07
+	Mm
		193165 YKT6_MOUSE (1-198): 1.76e-73: 222: 92.93		BET1_MOUSE (149-234): 6.68e-26: 99.1: 22.09
+	Rn
		1125559 YKT6_RAT (1-198): 8.39e-73: 220: 94.95		BET1_RAT (149-234): 6.68e-26: 99.1: 22.09
+	Hs
		169321 YKT6_HUMAN (1-198): 2.95e-72: 218: 100.00		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Sc
		701250 YKT6_YEAST (1-198): 9.98e-69: 209: 47.00		VAM7_YEAST (46-211): 1.29e-25: 103: 21.56
+	Sc
		611770 YKT6_YEAST (1-198): 9.98e-69: 209: 47.00		BET1_YEAST (93-235): 4.89e-27: 102: 18.06
+	Hs
		263128 SC22B_HUMAN (1-196): 2.72e-63: 196: 19.60		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		169333 SC22B_HUMAN (1-196): 2.72e-63: 196: 19.60		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Dm
		1374918 Q9W3M8_DROME (1-196): 9.21e-71: 215: 61.74		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00
+	Hs
		169416 VAMP7_HUMAN (28-193): 7.9e-57: 180: 22.03		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Dm
		115845 M9PGI6_DROME (3-195): 3.74e-59: 185: 21.03		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00