HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1308
+	Hs
		273310 SOCS5_HUMAN (3-210): 1.1e-46: 162: 19.44		ERBB4_HUMAN (1-1308): 0: 1394: 100.00
+	Hs
		913652 VAV2_HUMAN (1-175): 6.1e-39: 144: 17.68		ERBB4_HUMAN (1-1308): 0: 1394: 100.00
+	Hs
		193169 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		ERBB2_HUMAN (25-1274): 0: 1094: 45.98
+	Hs
		273299 SOCS5_HUMAN (3-210): 1.1e-46: 162: 19.44		ERBB2_HUMAN (25-1274): 0: 1094: 45.98
+	Hs
		273306 SOCS5_HUMAN (3-210): 1.1e-46: 162: 19.44		ERBB3_HUMAN (1-1258): 0: 1083: 47.41
+	Hs
		410727 VAV2_HUMAN (1-175): 6.1e-39: 144: 17.68		ERBB2_HUMAN (25-1274): 0: 1094: 45.98
+	Mm
		236701 SOCS5_MOUSE (3-210): 1.24e-45: 159: 19.44		EGFR_MOUSE (21-1286): 0: 1077: 49.69
+	Hs
		641536 VAV2_HUMAN (1-175): 6.1e-39: 144: 17.68		ERBB3_HUMAN (1-1258): 0: 1083: 47.41
+	Hs
		193165 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		EGFR_HUMAN (20-1286): 0: 1028: 48.70
+	Hs
		273298 SOCS5_HUMAN (3-210): 1.1e-46: 162: 19.44		EGFR_HUMAN (20-1286): 0: 1028: 48.70
+	Hs
		363635 SOCS4_HUMAN (3-210): 9.85e-43: 150: 18.98		EGFR_HUMAN (20-1286): 0: 1028: 48.70
+	Hs
		363013 VAV2_HUMAN (1-175): 6.1e-39: 144: 17.68		EGFR_HUMAN (20-1286): 0: 1028: 48.70
+	Hs
		155060 SOCS2_HUMAN (37-211): 1.63e-42: 143: 29.08		EGFR_HUMAN (20-1286): 0: 1028: 48.70
+	Mm
		205439 SOCS1_MOUSE (1-211): 4.05e-52: 168: 93.87		FAK2_MOUSE (676-1190): 4.21e-131: 430: 27.16
+	Hs
		193164 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		ABL1_HUMAN (693-1305): 2.94e-121: 406: 24.84
+	Hs
		193261 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		FAK1_HUMAN (703-997): 6.58e-59: 223: 39.53
+	Hs
		1060799 SOCS4_HUMAN (3-210): 9.85e-43: 150: 18.98		ACK1_HUMAN (697-970): 1.52e-54: 209: 40.43
+	Mm
		205419 SOCS1_MOUSE (1-211): 4.05e-52: 168: 93.87		INSR_MOUSE (353-660): 7.52e-32: 137: 19.05
+	Hs
		193183 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		IGF1R_HUMAN (333-691): 3.64e-32: 138: 18.37
+	Hs
		193174 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		INSR_HUMAN (353-660): 1.04e-31: 137: 19.05