HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.80	0.609

Property	Details
Experiments	17997974
Identification Methods	unspecified method, isothermal titration calorimetry
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 440
+	Mm
		236701 EGFR_MOUSE (1-1210): 0: 1267: 90.35		SOCS5_MOUSE (7-436): 1.24e-130: 389: 52.26
+	Hs
		273298 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS5_HUMAN (7-436): 1.82e-134: 398: 52.72
+	Mm
		431341 EGFR_MOUSE (1-1210): 0: 1267: 90.35		SRC_MOUSE (171-389): 7.65e-45: 165: 12.45
+	Hs
		362614 EGFR_HUMAN (1-1210): 0: 1246: 100.00		YES_HUMAN (151-429): 1.78e-46: 170: 14.19
+	Rn
		1455868 Q9QX70_RAT (1-1210): 0: 1250: 90.34		SRC_RAT (133-389): 1.6e-44: 164: 12.45
+	Hs
		362677 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SRC_HUMAN (134-389): 9.3e-44: 162: 12.50
+	Hs
		155060 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS2_HUMAN (234-425): 1.65e-46: 160: 25.85
+	Hs
		193165 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS1_HUMAN (260-425): 3.01e-46: 160: 22.29
+	Hs
		362630 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HCK_HUMAN (132-430): 3.31e-43: 160: 14.89
+	Hs
		362594 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LCK_HUMAN (184-418): 4.67e-42: 157: 15.57
+	Hs
		362647 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FGR_HUMAN (186-433): 2.07e-41: 155: 16.92
+	Hs
		155989 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS6_HUMAN (220-424): 7.37e-41: 154: 29.22
+	Hs
		362927 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FRK_HUMAN (182-399): 2.25e-40: 152: 16.00
+	Hs
		362615 EGFR_HUMAN (1-1210): 0: 1246: 100.00		LYN_HUMAN (163-433): 8.16e-40: 151: 16.43
+	Hs
		155889 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SOCS3_HUMAN (250-422): 1.63e-37: 138: 20.09
+	Hs
		362911 EGFR_HUMAN (1-1210): 0: 1246: 100.00		CSK_HUMAN (245-379): 2.96e-33: 131: 19.12
+	Hs
		362717 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PLCG2_HUMAN (258-399): 9.79e-23: 103: 18.88
+	Hs
		362745 EGFR_HUMAN (1-1210): 0: 1246: 100.00		PLCG1_HUMAN (271-379): 4.45e-22: 101: 18.18
+	Hs
		136243 EGFR_HUMAN (1-1210): 0: 1246: 100.00		P85B_HUMAN (241-382): 2.39e-18: 89.5: 20.69
+	Hs
		362816 EGFR_HUMAN (1-1210): 0: 1246: 100.00		P85A_HUMAN (175-392): 1.31e-15: 81: 14.66