HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: TRIM8 (Q9BZR9)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29991678
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 211 Hs			1 551
+	Mm
		205437 SOCS1_MOUSE (1-211): 4.05e-52: 168: 93.87		TRIM8_MOUSE (1-551): 7.57e-140: 417: 97.64
+	Hs
		193304 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		TRIM5_HUMAN (1-521): 2.47e-77: 254: 14.03
+	Hs
		222011 NCK2_HUMAN (2-175): 1.5e-38: 138: 19.77		TRI27_HUMAN (1-525): 3.27e-78: 256: 12.59
+	Hs
		440331 FYN_HUMAN (64-194): 7.24e-37: 136: 18.44		TRI27_HUMAN (1-525): 3.27e-78: 256: 12.59
+	Hs
		440739 FYN_HUMAN (64-194): 7.24e-37: 136: 18.44		TRI39_HUMAN (6-525): 3e-77: 254: 13.95
+	Hs
		463214 YES_HUMAN (64-196): 3.83e-35: 131: 16.08		TRIM5_HUMAN (1-521): 2.47e-77: 254: 14.03
+	Hs
		594108 NCK1_HUMAN (17-175): 4.03e-36: 131: 21.25		TRI39_HUMAN (6-525): 3e-77: 254: 13.95
+	Hs
		571924 GRB2_HUMAN (52-181): 1.5e-35: 126: 16.79		TRI27_HUMAN (1-525): 3.27e-78: 256: 12.59
+	Hs
		987957 GRB2_HUMAN (52-181): 1.5e-35: 126: 16.79		TRI39_HUMAN (6-525): 3e-77: 254: 13.95
+	Hs
		1125169 SOCS4_HUMAN (3-210): 9.85e-43: 150: 18.98		TRI25_HUMAN (8-364): 5.86e-57: 203: 22.64
+	Hs
		440665 FYN_HUMAN (64-194): 7.24e-37: 136: 18.44		TRI63_HUMAN (2-347): 1.21e-58: 200: 19.67
+	Hs
		440716 FYN_HUMAN (64-194): 7.24e-37: 136: 18.44		TRI55_HUMAN (2-347): 8.36e-53: 190: 19.45
+	Hs
		440244 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		TRI35_HUMAN (6-289): 6.75e-49: 178: 26.12
+	Hs
		699745 P85A_HUMAN (53-180): 1.36e-23: 99.7: 20.00		TRI25_HUMAN (8-364): 5.86e-57: 203: 22.64
+	Hs
		1324819 Q8N381_HUMAN (79-179): 5.77e-24: 100: 21.91		TRI54_HUMAN (2-347): 5.35e-58: 199: 17.76
+	Hs
		1364868 P55G_HUMAN (79-179): 6.12e-24: 100: 21.91		TRI54_HUMAN (2-347): 5.35e-58: 199: 17.76