HitPredict

Interactor 1: PER1 (O15534)
Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)
Gene: PER1

Interactor 2: KC1D (P48730)
Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
Gene: CSNK1D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	11165242, 28514442, 33961781, 32707033, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032922 - circadian regulation of gene expression and 1 others more... GO:0042752 - regulation of circadian rhythm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1290 Hs			1 415
+	Mm
		205755 PER1_MOUSE (1-1290): 5.71e-166: 531: 91.27		KC1D_MOUSE (1-415): 6.24e-141: 410: 99.76
+	Hs
		193760 PER1_HUMAN (1-1290): 8.53e-167: 533: 100.00		KC1E_HUMAN (1-409): 3.68e-124: 367: 82.69
+	Mm
		205756 PER1_MOUSE (1-1290): 5.71e-166: 531: 91.27		KC1E_MOUSE (1-409): 7.63e-124: 366: 82.93
+	Mm
		205752 PER1_MOUSE (1-1290): 5.71e-166: 531: 91.27		KC1A_MOUSE (2-327): 1.18e-123: 363: 69.02
+	Hs
		193772 PER1_HUMAN (1-1290): 8.53e-167: 533: 100.00		KC1G2_HUMAN (3-367): 1.21e-118: 353: 48.23
+	Hs
		176164 PER2_HUMAN (26-1242): 5.77e-130: 433: 40.68		KC1D_HUMAN (1-415): 5.91e-141: 410: 100.00
+	Hs
		176166 PER2_HUMAN (26-1242): 5.77e-130: 433: 40.68		KC1E_HUMAN (1-409): 3.68e-124: 367: 82.69
+	Hs
		877127 HIF1A_HUMAN (112-869): 1.57e-117: 388: 11.34		KC1D_HUMAN (1-415): 5.91e-141: 410: 100.00
+	Mm
		236766 PER2_MOUSE (26-1239): 8.2e-113: 385: 35.47		KC1D_MOUSE (1-415): 6.24e-141: 410: 99.76
+	Mm
		1440945 BMAL1_MOUSE (32-667): 1.27e-118: 385: 14.98		KC1E_MOUSE (1-409): 7.63e-124: 366: 82.93
+	Mm
		236768 PER2_MOUSE (26-1239): 8.2e-113: 385: 35.47		KC1E_MOUSE (1-409): 7.63e-124: 366: 82.93
+	Mm
		236758 PER2_MOUSE (26-1239): 8.2e-113: 385: 35.47		KC1A_MOUSE (2-327): 1.18e-123: 363: 69.02
+	Hs
		132706 BMAL1_HUMAN (32-667): 3.4e-113: 370: 14.96		KC1E_HUMAN (1-409): 3.68e-124: 367: 82.69
+	Hs
		877077 PER3_HUMAN (125-1216): 7.31e-91: 322: 33.50		KC1D_HUMAN (1-415): 5.91e-141: 410: 100.00
+	Hs
		885733 PER3_HUMAN (125-1216): 7.31e-91: 322: 33.50		KC1E_HUMAN (1-409): 3.68e-124: 367: 82.69
+	Hs
		192905 CLOCK_HUMAN (103-949): 4.39e-83: 292: 11.41		KC1E_HUMAN (1-409): 3.68e-124: 367: 82.69
+	Mm
		148287 CLOCK_MOUSE (103-960): 5.58e-80: 284: 11.28		KC1E_MOUSE (1-409): 7.63e-124: 366: 82.93
+	Dm
		303768 PER_DROME (217-575): 3.74e-76: 278: 27.20		DCO_DROME (1-339): 6.45e-123: 364: 76.99
+	Dm
		458801 PER_DROME (217-575): 3.74e-76: 278: 27.20		KC1A_DROME (2-321): 3.63e-122: 359: 63.98
+	Dm
		263800 CLOCK_DROME (198-463): 5.93e-27: 121: 19.80		DCO_DROME (1-339): 6.45e-123: 364: 76.99