Protein: PER1
Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)

Gene: PER1
Organism: Homo sapiens
Interactions: 109
UniProt ID: O15534

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding
GO:0002028 - regulation of sodium ion transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193779

CRY1
Cryptochrome-1

6

20

Small-scale

0.942

High

193784

CRY2
Cryptochrome-2

3

20

High-throughput

0.849

High

176105

PER2
Period circadian protein homolog 2

2

20

High-throughput

0.793

High

193764

PER3
Period circadian protein homolog 3

2

19

Small-scale

0.789

High

193760

KC1E
Casein kinase I isoform epsilon

9

20

Small-scale

0.760

High

193758

KC1D
Casein kinase I isoform delta

5

20

Small-scale

0.716

High

193803

BMAL2
Basic helix-loop-helix ARNT-like protein 2

1

19

High-throughput

0.691

High

193809

NPAS1
Neuronal PAS domain-containing protein 1

1

20

High-throughput

0.691

High

193807

AP2M1
AP-2 complex subunit mu

3

2

High-throughput

0.667

High

193777

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

0

High-throughput

0.638

High

193834

TX264
Testis-expressed protein 264

3

0

High-throughput

0.638

High

193828

FBW1B
F-box/WD repeat-containing protein 11

2

10

Small-scale

0.634

High

193831

FBW1A
F-box/WD repeat-containing protein 1A

2

11

Small-scale

0.634

High

193783

KLH40
Kelch-like protein 40

2

3

High-throughput

0.628

High

193818

TXNIP
Thioredoxin-interacting protein

2

3

High-throughput

0.628

High

193756

RHG25
Rho GTPase-activating protein 25

3

1

High-throughput

0.609

High

193732

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.602

High

193780

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

2

0

High-throughput

0.602

High

193795

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.602

High

193814

NXF2
Nuclear RNA export factor 2

2

0

High-throughput

0.602

High

193806

RBPMS
RNA-binding protein with multiple splicing

2

2

High-throughput

0.584

High

193785

TENS2
Tensin-2

2

3

High-throughput

0.576

High

193797

GP156
Probable G-protein coupled receptor 156

2

1

High-throughput

0.574

High

193772

KC1G2
Casein kinase I isoform gamma-2

1

20

Small-scale

0.561

High

193820

LT4R2
Leukotriene B4 receptor 2

1

1

High-throughput

0.541

High

158382

RFXK
DNA-binding protein RFXANK

1

2

High-throughput

0.536

High

183402

CASC3
Protein CASC3

1

1

High-throughput

0.536

High

193749

CRCM
Colorectal mutant cancer protein

1

9

High-throughput

0.536

High

193753

GRK4
G protein-coupled receptor kinase 4

1

7

High-throughput

0.536

High

193769

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

5

High-throughput

0.536

High

193773

FOXK2
Forkhead box protein K2

1

6

High-throughput

0.536

High

193786

LAR1B
La-related protein 1B

1

1

High-throughput

0.536

High

193801

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

3

High-throughput

0.536

High

193808

PPM1M
Protein phosphatase 1M

1

2

High-throughput

0.536

High

193815

DRC3
Dynein regulatory complex subunit 3

1

2

High-throughput

0.536

High

193816

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

1

High-throughput

0.536

High

193823

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.536

High

193832

NISCH
Nischarin

1

3

High-throughput

0.536

High

193789

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.529

High

167197

KLF11
Krueppel-like factor 11

1

4

High-throughput

0.515

High

193733

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.515

High

193736

PR40A
Pre-mRNA-processing factor 40 homolog A

1

8

High-throughput

0.515

High

193741

RASH
GTPase HRas

1

4

High-throughput

0.515

High

193742

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.515

High

193743

GELS
Gelsolin

1

3

High-throughput

0.515

High

193744

PDIA1
Protein disulfide-isomerase

1

2

High-throughput

0.515

High

193745

GFAP
Glial fibrillary acidic protein

1

2

High-throughput

0.515

High

193755

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.515

High

193757

BAG6
Large proline-rich protein BAG6

1

12

High-throughput

0.515

High

193759

SYSC
Serine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

193761

HSP72
Heat shock-related 70 kDa protein 2

1

7

High-throughput

0.515

High

193763

CASP6
Caspase-6

1

3

High-throughput

0.515

High

193768

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.515

High

193810

TCPH
T-complex protein 1 subunit eta

1

4

High-throughput

0.515

High

193829

UBQL1
Ubiquilin-1

1

2

High-throughput

0.515

High

193735

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

193737

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.513

High

193771

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.513

High

193776

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.513

High

193787

PADI6
Inactive protein-arginine deiminase type-6

1

0

High-throughput

0.513

High

193792

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.513

High

193805

RENT1
Regulator of nonsense transcripts 1

1

0

High-throughput

0.513

High

193811

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

0

High-throughput

0.513

High

193812

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

193813

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

193817

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.513

High

193821

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

193824

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

193734

NUPR1
Nuclear protein 1

1

0

High-throughput

0.493

High

193738

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.493

High

193739

WFS1
Wolframin

1

0

High-throughput

0.493

High

193752

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.493

High

193767

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

193800

BRK1
Protein BRICK1

1

0

High-throughput

0.493

High

193804

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

193740

FA12
Coagulation factor XII

1

4

High-throughput

0.489

High

193750

CRBB3
Beta-crystallin B3

1

1

High-throughput

0.489

High

193781

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

193793

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

2

High-throughput

0.489

High

193794

KLH34
Kelch-like protein 34

1

4

High-throughput

0.489

High

193770

CSK2B
Casein kinase II subunit beta

1

7

High-throughput

0.481

High

193778

TRIP6
Thyroid receptor-interacting protein 6

1

3

High-throughput

0.481

High

193782

CCD57
Coiled-coil domain-containing protein 57

1

9

High-throughput

0.481

High

193796

PNMA1
Paraneoplastic antigen Ma1

1

1

High-throughput

0.481

High

172282

XPO1
Exportin-1

1

10

High-throughput

0.479

High

193748

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

5

High-throughput

0.479

High

193754

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

193762

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

1

High-throughput

0.479

High

193765

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

193790

RFPLB
Ret finger protein-like 4B

1

3

High-throughput

0.479

High

193791

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.479

High

193830

TRI33
E3 ubiquitin-protein ligase TRIM33

1

18

High-throughput

0.479

High

193747

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.470

High

193774

Q0VDC6
peptidylprolyl isomerase

1

1

High-throughput

0.470

High

193775

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

1

High-throughput

0.470

High

193802

JPH3
Junctophilin-3

1

1

High-throughput

0.470

High

193833

RIPR2
Rho family-interacting cell polarization regulator 2

1

0

High-throughput

0.460

High

193746

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

58761

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

2

High-throughput

0.445

High

193819

E41L1
Band 4.1-like protein 1

1

5

High-throughput

0.445

High

193827

DEC1
Deleted in esophageal cancer 1

1

4

High-throughput

0.439

High

193788

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.407

High

193825

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

4

High-throughput

0.407

High

193822

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

3

0

High-throughput

0.347

High

193798

DQX1
ATP-dependent RNA helicase homolog DQX1

2

0

High-throughput

0.328

High

193799

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

193751

GRN
Progranulin

1

0

High-throughput

0.268

Low

193766

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.268

Low

193826

Q9P1I4
PRO0786

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025