Protein: PER2
Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)

Gene: PER2
Organism: Homo sapiens
Interactions: 140
UniProt ID: O15055

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0001222 - transcription corepressor binding
GO:0002931 - response to ischemia
GO:0003407 - neural retina development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176202

CRY1
Cryptochrome-1

9

20

Small-scale

0.968

High

176204

CRY2
Cryptochrome-2

5

20

Small-scale

0.922

High

176105

PER1
Period circadian protein homolog 1

2

20

High-throughput

0.793

High

176166

KC1E
Casein kinase I isoform epsilon

8

20

Small-scale

0.749

High

176164

KC1D
Casein kinase I isoform delta

6

20

Small-scale

0.731

High

176234

FBW1A
F-box/WD repeat-containing protein 1A

5

10

Small-scale

0.711

High

176183

MDM2
E3 ubiquitin-protein ligase Mdm2

3

3

Small-scale

0.674

High

117134

J3QSH9
Period circadian regulator 1

1

19

High-throughput

0.665

High

176118

P53
Cellular tumor antigen p53

2

7

Small-scale

0.651

High

176104

CLOCK
Circadian locomoter output cycles protein kaput

1

19

High-throughput

0.621

High

132683

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

19

Small-scale

0.618

High

176128

HS90A
Heat shock protein HSP 90-alpha

1

16

Small-scale

0.618

High

176136

ENPL
Endoplasmin

1

16

Small-scale

0.618

High

176172

PER3
Period circadian protein homolog 3

1

20

Small-scale

0.618

High

176232

FBW1B
F-box/WD repeat-containing protein 11

2

9

High-throughput

0.611

High

176131

UBL4A
Ubiquitin-like protein 4A

2

7

High-throughput

0.606

High

176175

LMO4
LIM domain transcription factor LMO4

2

4

High-throughput

0.606

High

176157

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

176193

ELOA1
Elongin-A

2

0

High-throughput

0.580

High

176221

LENG8
Leukocyte receptor cluster member 8

2

0

High-throughput

0.580

High

176121

JUN
Transcription factor Jun

1

13

High-throughput

0.536

High

176149

CRCM
Colorectal mutant cancer protein

1

10

High-throughput

0.536

High

176184

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.536

High

176187

GOGA3
Golgin subfamily A member 3

1

9

High-throughput

0.536

High

176191

PLD1
Phospholipase D1

1

2

High-throughput

0.536

High

176196

SLMAP
Sarcolemmal membrane-associated protein

1

8

High-throughput

0.536

High

176197

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

4

High-throughput

0.536

High

176206

ZN618
Zinc finger protein 618

1

2

High-throughput

0.536

High

176212

DZIP1
Cilium assembly protein DZIP1

1

10

High-throughput

0.536

High

176216

ASPM
Abnormal spindle-like microcephaly-associated protein

1

11

High-throughput

0.536

High

176217

APBP2
Amyloid protein-binding protein 2

1

4

High-throughput

0.536

High

176224

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

1

High-throughput

0.536

High

176227

SAV1
Protein salvador homolog 1

1

5

High-throughput

0.536

High

176150

MCM3
DNA replication licensing factor MCM3

1

5

Small-scale

0.515

High

176151

PML
Protein PML

1

13

Small-scale

0.515

High

51622

CBAR1
CBY1-interacting BAR domain-containing protein 1

1

0

High-throughput

0.513

High

176189

WASC5
WASH complex subunit 5

1

0

High-throughput

0.513

High

176203

WASC4
WASH complex subunit 4

1

0

High-throughput

0.513

High

176205

CEP78
Centrosomal protein of 78 kDa

1

0

High-throughput

0.513

High

176208

TTLL5
Tubulin polyglutamylase TTLL5

1

0

High-throughput

0.513

High

176209

FA83H
Protein FAM83H

1

0

High-throughput

0.513

High

176210

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.513

High

176220

REXO5
RNA exonuclease 5

1

0

High-throughput

0.513

High

176132

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

Small-scale

0.493

High

176142

HXK1
Hexokinase-1

1

0

Small-scale

0.493

High

176168

RORG
Nuclear receptor ROR-gamma

1

20

High-throughput

0.481

High

176180

CSK2B
Casein kinase II subunit beta

1

7

High-throughput

0.481

High

176226

BHE41
Class E basic helix-loop-helix protein 41

1

19

High-throughput

0.481

High

168587

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.480

High

176106

ACTN4
Alpha-actinin-4

1

2

Small-scale

0.479

High

176108

MAGC1
Melanoma-associated antigen C1

1

13

Small-scale

0.479

High

176110

KPCD3
Serine/threonine-protein kinase D3

1

8

Small-scale

0.479

High

176112

NB5R3
NADH-cytochrome b5 reductase 3

1

1

Small-scale

0.479

High

176113

PGK1
Phosphoglycerate kinase 1

1

1

Small-scale

0.479

High

176115

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

Small-scale

0.479

High

176119

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

4

Small-scale

0.479

High

176120

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

Small-scale

0.479

High

176122

LA
Lupus La protein

1

1

Small-scale

0.479

High

176123

GELS
Gelsolin

1

3

Small-scale

0.479

High

176126

H2B1J
Histone H2B type 1-J

1

1

Small-scale

0.479

High

176127

PDIA1
Protein disulfide-isomerase

1

2

Small-scale

0.479

High

176129

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

Small-scale

0.479

High

176133

ACTN1
Alpha-actinin-1

1

2

Small-scale

0.479

High

176134

EF2
Elongation factor 2

1

2

Small-scale

0.479

High

176137

EZRI
Ezrin

1

3

Small-scale

0.479

High

176138

NDKA
Nucleoside diphosphate kinase A

1

1

Small-scale

0.479

High

176139

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

Small-scale

0.479

High

176140

KPCA
Protein kinase C alpha type

1

7

Small-scale

0.479

High

176141

EGR1
Early growth response protein 1

1

4

High-throughput

0.479

High

176143

FLNA
Filamin-A

1

4

Small-scale

0.479

High

176146

NDKB
Nucleoside diphosphate kinase B

1

1

Small-scale

0.479

High

176147

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

Small-scale

0.479

High

176148

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

Small-scale

0.479

High

176152

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

2

Small-scale

0.479

High

176153

SPRE
Sepiapterin reductase

1

1

Small-scale

0.479

High

176154

TAGL2
Transgelin-2

1

2

Small-scale

0.479

High

176158

MDHM
Malate dehydrogenase, mitochondrial

1

1

Small-scale

0.479

High

176160

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

Small-scale

0.479

High

176161

MATR3
Matrin-3

1

3

Small-scale

0.479

High

176162

PRS6B
26S proteasome regulatory subunit 6B

1

4

Small-scale

0.479

High

176165

FAS
Fatty acid synthase

1

1

Small-scale

0.479

High

176167

TCPQ
T-complex protein 1 subunit theta

1

2

Small-scale

0.479

High

176169

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

Small-scale

0.479

High

176170

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

176171

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

3

Small-scale

0.479

High

176173

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

2

Small-scale

0.479

High

176177

RAB1A
Ras-related protein Rab-1A

1

1

Small-scale

0.479

High

176179

1433Z
14-3-3 protein zeta/delta

1

4

Small-scale

0.479

High

176181

TCPB
T-complex protein 1 subunit beta

1

2

Small-scale

0.479

High

176185

K1C17
Keratin, type I cytoskeletal 17

1

1

Small-scale

0.479

High

176186

CKAP4
Cytoskeleton-associated protein 4

1

12

Small-scale

0.479

High

176190

ACACA
Acetyl-CoA carboxylase 1

1

4

Small-scale

0.479

High

176192

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.479

High

176194

FLNC
Filamin-C

1

5

Small-scale

0.479

High

176195

IMB1
Importin subunit beta-1

1

3

Small-scale

0.479

High

176199

KPCD1
Serine/threonine-protein kinase D1

1

8

Small-scale

0.479

High

176200

PLEC
Plectin

1

2

Small-scale

0.479

High

176201

SEPT7
Septin-7

1

2

Small-scale

0.479

High

176211

MYH14
Myosin-14

1

8

Small-scale

0.479

High

176222

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

Small-scale

0.479

High

176223

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

Small-scale

0.479

High

176225

TCPH
T-complex protein 1 subunit eta

1

1

Small-scale

0.479

High

176228

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

3

Small-scale

0.479

High

176233

RALY
RNA-binding protein Raly

1

1

Small-scale

0.479

High

176237

TLN1
Talin-1

1

9

Small-scale

0.479

High

176135

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.460

High

65653

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

Small-scale

0.458

High

176107

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

Small-scale

0.458

High

176109

CISY
Citrate synthase, mitochondrial

1

0

Small-scale

0.458

High

176111

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

Small-scale

0.458

High

176114

K2C6A
Keratin, type II cytoskeletal 6A

1

0

Small-scale

0.458

High

176116

TFR1
Transferrin receptor protein 1

1

0

Small-scale

0.458

High

176117

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.458

High

176124

ENOA
Alpha-enolase

1

0

Small-scale

0.458

High

176125

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.458

High

176130

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

Small-scale

0.458

High

176144

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

Small-scale

0.458

High

176145

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

Small-scale

0.458

High

176155

RS19
Small ribosomal subunit protein eS19

1

0

Small-scale

0.458

High

176163

CAPZB
F-actin-capping protein subunit beta

1

0

Small-scale

0.458

High

176176

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

176178

RL39
Large ribosomal subunit protein eL39

1

0

Small-scale

0.458

High

176182

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.458

High

176188

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.458

High

176214

HID1
Protein HID1

1

0

Small-scale

0.458

High

176230

AKIP
Small ribosomal subunit protein mS38

1

0

Small-scale

0.458

High

176236

RL36
Large ribosomal subunit protein eL36

1

0

Small-scale

0.458

High

176231

DEC1
Deleted in esophageal cancer 1

1

4

High-throughput

0.439

High

176174

RAB5B
Ras-related protein Rab-5B

1

1

Small-scale

0.437

High

176198

PDIA6
Protein disulfide-isomerase A6

1

2

Small-scale

0.437

High

176213

CPNE8
Copine-8

1

2

Small-scale

0.437

High

176215

CPNE9
Copine-9

1

2

Small-scale

0.437

High

90695

WASH3
Putative WAS protein family homolog 3

1

0

High-throughput

0.426

High

176207

WAC2A
WASH complex subunit 2A

1

0

High-throughput

0.426

High

176235

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

176156

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

Small-scale

0.249

Low

176159

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.249

Low

176218

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

176219

ERO1A
ERO1-like protein alpha

1

0

Small-scale

0.249

Low

176229

APMAP
Adipocyte plasma membrane-associated protein

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025