HitPredict

Interactor 1: SH21B (O35324)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: Sh2d1b

Interactor 2: SLAF1 (Q9QUM4)
Signaling lymphocytic activation molecule (SLAM family member 1) (CD antigen CD150)
Gene: Slamf1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.526

Property	Details
Experiments	11689425
Identification Methods	fluorescence polarization spectroscopy, two hybrid
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response GO:0032689 - negative regulation of type II interferon production
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Mm			1 343
+	Mm
		313108 SH21A_MOUSE (6-105): 2.96e-45: 145: 39.00		SLAF1_MOUSE (1-343): 1.66e-91: 278: 100.00
+	Mm
		1135290 Q149T1_MOUSE (1-132): 8.68e-44: 141: 98.49		SLAF1_MOUSE (1-343): 1.66e-91: 278: 100.00
+	Mm
		1192885 SH21C_MOUSE (1-132): 3.8e-43: 140: 84.09		SLAF1_MOUSE (1-343): 1.66e-91: 278: 100.00
+	Hs
		258595 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		SLAF1_HUMAN (1-343): 2.33e-80: 250: 59.77
+	Hs
		1101292 SHIP1_HUMAN (5-102): 6.91e-38: 137: 35.71		SLAF1_HUMAN (1-343): 2.33e-80: 250: 59.77
+	Hs
		164857 SH21B_HUMAN (1-132): 5.09e-41: 134: 65.15		SLAF1_HUMAN (1-343): 2.33e-80: 250: 59.77
+	Hs
		258611 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		SLAF6_HUMAN (13-338): 3.25e-63: 205: 19.35
+	Mm
		1060054 Q149T1_MOUSE (1-132): 8.68e-44: 141: 98.49		CD244_MOUSE (31-329): 3.39e-61: 202: 23.53
+	Hs
		258613 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		CD244_HUMAN (39-339): 6.37e-60: 198: 21.68
+	Hs
		164869 SH21B_HUMAN (1-132): 5.09e-41: 134: 65.15		SLAF6_HUMAN (13-338): 3.25e-63: 205: 19.35
+	Hs
		1369278 SHIP1_HUMAN (5-102): 6.91e-38: 137: 35.71		CD244_HUMAN (39-339): 6.37e-60: 198: 21.68
+	Mm
		204678 SH21B_MOUSE (1-132): 1.85e-43: 140: 100.00		SLAF7_MOUSE (12-342): 1.11e-50: 173: 18.45
+	Hs
		258616 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		SLAF7_HUMAN (5-342): 4.07e-49: 169: 17.78
+	Hs
		258619 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		SLAF5_HUMAN (7-342): 2.48e-48: 167: 19.77
+	Hs
		1369280 SHIP1_HUMAN (5-102): 6.91e-38: 137: 35.71		SLAF7_HUMAN (5-342): 4.07e-49: 169: 17.78
+	Hs
		258615 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		LY9_HUMAN (30-279): 8.91e-25: 107: 18.18
+	Hs
		1369279 SHIP1_HUMAN (5-102): 6.91e-38: 137: 35.71		LY9_HUMAN (30-279): 8.91e-25: 107: 18.18
+	Hs
		224533 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		SIGL6_HUMAN (80-217): 7.67e-23: 100: 21.09
+	Hs
		258620 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		SIGL7_HUMAN (46-248): 4.63e-20: 92.7: 15.60
+	Hs
		188586 SH21A_HUMAN (6-105): 2.9e-44: 142: 39.00		SIGL5_HUMAN (26-213): 6.97e-18: 86.5: 19.51