HitPredict

Interactor 1: SIGL6 (O43699)
Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
Gene: SIGLEC6

Interactor 2: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19150402
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 453 Hs			1 128
+	Hs
		258620 SIGL7_HUMAN (23-453): 1.59e-73: 240: 50.11		SH21A_HUMAN (1-128): 5.2e-38: 126: 100.00
+	Hs
		463325 CD22_HUMAN (30-452): 1.8e-43: 165: 17.95		LYN_HUMAN (1-125): 1.58e-39: 139: 19.85
+	Hs
		629550 CD22_HUMAN (30-452): 1.8e-43: 165: 17.95		SHIP1_HUMAN (4-103): 1.67e-37: 136: 43.00
+	Hs
		258587 CD22_HUMAN (30-452): 1.8e-43: 165: 17.95		SH21A_HUMAN (1-128): 5.2e-38: 126: 100.00
+	Hs
		629547 CD22_HUMAN (30-452): 1.8e-43: 165: 17.95		GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69
+	Hs
		557081 CD33_HUMAN (143-452): 6.32e-39: 146: 20.23		SRC_HUMAN (1-127): 1.8e-38: 137: 20.90
+	Hs
		463499 PTK7_HUMAN (27-445): 1.18e-30: 127: 13.77		LYN_HUMAN (1-125): 1.58e-39: 139: 19.85
+	Dm
		233626 O44924_DROME (2-253): 3.12e-26: 114: 14.40		ABL_DROME (1-127): 6.56e-39: 140: 27.82
+	Hs
		188586 SIGL5_HUMAN (44-453): 1.82e-28: 119: 17.12		SH21A_HUMAN (1-128): 5.2e-38: 126: 100.00
+	Hs
		440359 MAG_HUMAN (7-451): 3.52e-24: 107: 13.76		FYN_HUMAN (1-125): 4.26e-37: 133: 19.26
+	Hs
		629546 CD22_HUMAN (30-452): 1.8e-43: 165: 17.95		KSYK_HUMAN (6-120): 2.75e-15: 72.8: 25.86
+	Hs
		462981 VCAM1_HUMAN (105-365): 6.9e-20: 94.4: 19.42		YES_HUMAN (1-127): 5.29e-40: 141: 19.40
+	Hs
		463875 ROBO1_HUMAN (242-442): 1.48e-18: 90.9: 14.22		LYN_HUMAN (1-125): 1.58e-39: 139: 19.85
+	Hs
		463779 ROBO2_HUMAN (240-448): 3.45e-18: 89.7: 15.42		LYN_HUMAN (1-125): 1.58e-39: 139: 19.85
+	Hs
		187285 VCAM1_HUMAN (105-365): 6.9e-20: 94.4: 19.42		SHIP2_HUMAN (3-122): 1.12e-34: 128: 37.50
+	Hs
		557323 MYLK_HUMAN (246-337): 9.09e-16: 82.4: 20.20		SRC_HUMAN (1-127): 1.8e-38: 137: 20.90
+	Hs
		628348 CD33_HUMAN (143-452): 6.32e-39: 146: 20.23		KSYK_HUMAN (6-120): 2.75e-15: 72.8: 25.86
+	Hs
		619714 VCAM1_HUMAN (105-365): 6.9e-20: 94.4: 19.42		GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69
+	Hs
		164877 ROBO1_HUMAN (242-442): 1.48e-18: 90.9: 14.22		SH21B_HUMAN (5-119): 3.06e-34: 117: 42.61
+	Hs
		619585 VCAM1_HUMAN (105-365): 6.9e-20: 94.4: 19.42		KSYK_HUMAN (6-120): 2.75e-15: 72.8: 25.86