Protein: CD244
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)

Gene: CD244
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q9BZW8

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002323 - natural killer cell activation involved in immune response
GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

480455

CD48
CD48 antigen

3

19

Small-scale

0.827

High

258613

SH21A
SH2 domain-containing protein 1A

12

20

Small-scale

0.756

High

839357

MTOR
Serine/threonine-protein kinase mTOR

3

6

High-throughput

0.667

High

1402462

MYADM
Myeloid-associated differentiation marker

3

2

High-throughput

0.667

High

281656

MTX2
Metaxin-2

4

2

High-throughput

0.630

High

1369278

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

2

13

Small-scale

0.625

High

164873

SH21B
SH2 domain-containing protein 1B

2

20

Small-scale

0.624

High

273229

CAND2
Cullin-associated NEDD8-dissociated protein 2

3

7

High-throughput

0.609

High

326866

RIMB1
Peripheral-type benzodiazepine receptor-associated protein 1

3

3

High-throughput

0.609

High

1204946

MTX3
Metaxin-3

3

2

High-throughput

0.609

High

1243232

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

3

2

High-throughput

0.609

High

1420331

POMT2
Protein O-mannosyl-transferase 2

3

6

High-throughput

0.609

High

1420333

POMT1
Protein O-mannosyl-transferase 1

3

6

High-throughput

0.609

High

1411594

MIC25
MICOS complex subunit MIC25

3

1

High-throughput

0.604

High

1420324

RAB18
Ras-related protein Rab-18

2

7

High-throughput

0.601

High

440719

FYN
Tyrosine-protein kinase Fyn

2

13

Small-scale

0.571

High

711188

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.571

High

1053738

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.565

High

317922

LTN1
E3 ubiquitin-protein ligase listerin

2

1

High-throughput

0.558

High

1230758

HEAT6
HEAT repeat-containing protein 6

2

2

High-throughput

0.558

High

1420322

HEAT1
HEAT repeat-containing protein 1

2

2

High-throughput

0.558

High

1420328

UFSP2
Ufm1-specific protease 2

2

4

High-throughput

0.558

High

1420334

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

2

8

High-throughput

0.558

High

619105

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

4

Small-scale

0.550

High

1211201

ODR4
Protein odr-4 homolog

2

3

High-throughput

0.549

High

1420332

SAM50
Sorting and assembly machinery component 50 homolog

2

1

High-throughput

0.549

High

557456

SRC
Proto-oncogene tyrosine-protein kinase Src

1

13

High-throughput

0.536

High

1116945

AT1A4
Sodium/potassium-transporting ATPase subunit alpha-4

1

6

High-throughput

0.536

High

599307

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

4

Small-scale

0.501

High

1121980

ARHG7
Rho guanine nucleotide exchange factor 7

1

2

Small-scale

0.500

High

1041696

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

3

High-throughput

0.489

High

1311100

UBR1
E3 ubiquitin-protein ligase UBR1

1

2

High-throughput

0.489

High

1384666

ELMO3
Engulfment and cell motility protein 3

1

1

High-throughput

0.489

High

1420323

AT131
Endoplasmic reticulum transmembrane helix translocase

1

9

High-throughput

0.489

High

1420326

PYRG2
CTP synthase 2

1

1

High-throughput

0.489

High

1420330

GPN3
GPN-loop GTPase 3

1

1

High-throughput

0.489

High

699845

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

High-throughput

0.479

High

963538

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

11

Small-scale

0.479

High

1004312

3BP2
SH3 domain-binding protein 2

1

3

Small-scale

0.457

High

471754

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

14

Small-scale

0.445

High

720531

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.445

High

834227

CSK
Tyrosine-protein kinase CSK

1

13

Small-scale

0.445

High

987921

GRB2
Growth factor receptor-bound protein 2

1

18

Small-scale

0.445

High

1122817

DOCK1
Dedicator of cytokinesis protein 1

1

6

High-throughput

0.445

High

1405478

S10AD
Protein S100-A13

1

5

High-throughput

0.445

High

1195689

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.437

High

1420335

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

8

High-throughput

0.437

High

183866

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

1

High-throughput

0.407

High

187404

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

7

Small-scale

0.407

High

999405

HBB
Hemoglobin subunit beta

1

2

High-throughput

0.407

High

1198145

RHG29
Rho GTPase-activating protein 29

1

1

High-throughput

0.407

High

1420327

MDN1
Midasin

1

2

High-throughput

0.407

High

1420329

MIC19
MICOS complex subunit MIC19

1

1

High-throughput

0.407

High

1224772

RN213
E3 ubiquitin-protein ligase RNF213

4

0

High-throughput

0.360

High

1397705

CAR19
Caspase recruitment domain-containing protein 19

4

0

High-throughput

0.360

High

1164550

MIC60
MICOS complex subunit MIC60

3

0

High-throughput

0.347

High

1420325

ST7
Suppressor of tumorigenicity 7 protein

2

0

High-throughput

0.318

High

1413961

TRMO
tRNA

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025