Interactor 1: SPIT1 (O43278)
Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)
Gene: SPINT1
Interactor 2: HGFA (Q04756)
Hepatocyte growth factor activator serine protease (HGF activator) (HGFA) (HGFA serine protease) (EC 3.4.21.-) (Serine protease HGFAC) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]
Gene: HGFAC
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.79 | 1.00 | 0.890 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 33961781, 20004165, 15713485, unassigned3799 |
| Identification Methods | affinity chromatography technology, enzyme linked immunosorbent assay, x-ray crystallography, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Kunitz_BPTI~Trypsin, Ldl_recept_a~Trypsin |
| Common GO terms | GO:0005576 - extracellular region GO:0005615 - extracellular space |
| Homologous interactions | 16 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
