Protein: HGFA
Hepatocyte growth factor activator serine protease (HGF activator) (HGFA) (HGFA serine protease) (EC 3.4.21.-) (Serine protease HGFAC) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]

Gene: HGFA, HGFAC
Organism: Homo sapiens
Interactions: 22
UniProt ID: Q04756

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005791 - rough endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211917

SPIT1
Kunitz-type protease inhibitor 1

4

16

Small-scale

0.890

High

212392

SPIT2
Kunitz-type protease inhibitor 2

3

15

High-throughput

0.855

High

425186

IPSP
Plasma serine protease inhibitor

2

20

High-throughput

0.811

High

939487

FCGRN
IgG receptor FcRn large subunit p51

2

10

High-throughput

0.811

High

1048267

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

5

High-throughput

0.700

High

571192

HGF
Hepatocyte growth factor

1

18

Small-scale

0.666

High

342400

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

2

High-throughput

0.628

High

1048277

RABX5
Rab5 GDP/GTP exchange factor

2

2

High-throughput

0.628

High

1048270

CCHCR
Coiled-coil alpha-helical rod protein 1

2

3

High-throughput

0.606

High

1048269

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.580

High

1048271

APBP2
Amyloid protein-binding protein 2

2

4

High-throughput

0.553

High

1048274

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

1

High-throughput

0.553

High

1048272

APBB2
Amyloid beta precursor protein binding family B member 2

2

2

High-throughput

0.549

High

62941

POTEF
POTE ankyrin domain family member F

1

4

High-throughput

0.536

High

1048266

TRI68
E3 ubiquitin-protein ligase TRIM68

1

1

High-throughput

0.536

High

1048275

TMX1
Thioredoxin-related transmembrane protein 1

1

8

High-throughput

0.536

High

873458

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

0

High-throughput

0.513

High

1048276

CENPH
Centromere protein H

1

0

High-throughput

0.513

High

472043

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.492

High

1007671

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.279

Low

1048268

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1048273

TMM74
Transmembrane protein 74

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025