Protein: FA12
Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]

Gene: FA12, F12
Organism: Homo sapiens
Interactions: 73
UniProt ID: P00748

Gene Ontology (top 5):
GO:0002353 - plasma kallikrein-kinin cascade
GO:0002542 - Factor XII activation
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366387

A4
Amyloid-beta precursor protein

1

20

High-throughput

0.665

High

366385

FA12
Coagulation factor XII

1

15

Small-scale

0.647

High

366388

GP1BA
Platelet glycoprotein Ib alpha chain

1

6

Small-scale

0.647

High

366410

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.647

High

366391

HSP7C
Heat shock cognate 71 kDa protein

2

5

High-throughput

0.628

High

366442

ARHG4
Rho guanine nucleotide exchange factor 4

1

2

High-throughput

0.618

High

366417

ANR40
Ankyrin repeat domain-containing protein 40

2

1

High-throughput

0.574

High

366386

TBB4A
Tubulin beta-4A chain

1

11

High-throughput

0.536

High

366389

TBB5
Tubulin beta chain

1

11

High-throughput

0.536

High

366393

HSP76
Heat shock 70 kDa protein 6

1

5

High-throughput

0.536

High

366403

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.536

High

366407

TBA4A
Tubulin alpha-4A chain

1

11

High-throughput

0.536

High

366408

PRAME
Melanoma antigen preferentially expressed in tumors

1

1

High-throughput

0.536

High

366421

TBA1A
Tubulin alpha-1A chain

1

12

High-throughput

0.536

High

366447

DD19B
ATP-dependent RNA helicase DDX19B

1

2

High-throughput

0.536

High

366448

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.536

High

366449

NEUR3
Sialidase-3

1

1

High-throughput

0.536

High

366413

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

Small-scale

0.528

High

366392

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.515

High

366394

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.513

High

366409

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.513

High

366428

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

0

High-throughput

0.513

High

366440

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

0

High-throughput

0.513

High

366445

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

0

High-throughput

0.513

High

366434

EPAS1
Endothelial PAS domain-containing protein 1

1

3

Small-scale

0.512

High

366404

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

5

Small-scale

0.501

High

366405

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

5

Small-scale

0.501

High

366406

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

5

Small-scale

0.501

High

76087

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.489

High

193740

PER1
Period circadian protein homolog 1

1

4

High-throughput

0.489

High

228782

SCO2
Protein SCO2 homolog, mitochondrial

1

2

High-throughput

0.489

High

314996

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.489

High

347450

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.489

High

366396

ETV3
ETS translocation variant 3

1

3

High-throughput

0.489

High

366401

DPOG1
DNA polymerase subunit gamma-1

1

1

High-throughput

0.489

High

366402

PMS1
PMS1 protein homolog 1

1

3

High-throughput

0.489

High

366411

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.489

High

366412

CUL7
Cullin-7

1

3

High-throughput

0.489

High

366416

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.489

High

366418

ACD10
Acyl-CoA dehydrogenase family member 10

1

2

High-throughput

0.489

High

366419

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

1

High-throughput

0.489

High

366423

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.489

High

366425

NEDD1
Protein NEDD1

1

1

High-throughput

0.489

High

366426

SHKB1
SH3KBP1-binding protein 1

1

2

High-throughput

0.489

High

366430

VCIP1
Deubiquitinating protein VCPIP1

1

1

High-throughput

0.489

High

366433

METH
Methionine synthase

1

1

High-throughput

0.489

High

366435

TEP1
Telomerase protein component 1

1

2

High-throughput

0.489

High

366436

TBA1C
Tubulin alpha-1C chain

1

12

High-throughput

0.489

High

366439

ESRP2
Epithelial splicing regulatory protein 2

1

3

High-throughput

0.489

High

366444

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.489

High

366446

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.489

High

366395

NF1
Neurofibromin

1

0

Small-scale

0.458

High

366399

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

5

Small-scale

0.457

High

366400

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

5

Small-scale

0.457

High

366390

HS71B
Heat shock 70 kDa protein 1B

1

5

High-throughput

0.445

High

177505

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

1

High-throughput

0.437

High

366424

PJA1
E3 ubiquitin-protein ligase Praja-1

1

2

High-throughput

0.437

High

296685

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

366398

CACP
Carnitine O-acetyltransferase

1

0

High-throughput

0.279

Low

366414

WDR81
WD repeat-containing protein 81

1

0

High-throughput

0.279

Low

366415

PR14L
Protein PRR14L

1

0

High-throughput

0.279

Low

366420

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.279

Low

366422

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.279

Low

366427

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.279

Low

366429

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

0

High-throughput

0.279

Low

366432

ATX2
Ataxin-2

1

0

High-throughput

0.279

Low

366437

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

366441

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

366443

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.279

Low

366431

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.249

Low

366438

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

High-throughput

0.249

Low

366397

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025